000			nab a22 7a 4500
999			_c17135 _d17135
003			PC17135
005			20230123114530.0
008			230123b xxu||||| |||| 00| 0 eng d
040			_cH12O
041			_aeng
100			_91893 _aAndrés Esteban, Eva _eInstituto de Investigación i+12
245	0	0	_aLower-normal TSH is associated with better metabolic risk factors: A cross-sectional study on Spanish men. _h[artículo]
260			_bNutrition, metabolism, and cardiovascular diseases : NMCD, _c2015
300			_a25(12):1095-103.
500			_aFormato Vancouver: Laclaustra M, Hurtado Roca Y, Sendín M, León M, Ledesma M, Andrés E et al. Lower-normal TSH is associated with better metabolic risk factors: A cross-sectional study on Spanish men. Nutr Metab Cardiovasc Dis. 2015 Dec;25(12):1095-103.
501			_aPMID: 26552743
504			_aContiene 61 referencias
520			_aBackground and aims: Subclinical thyroid conditions, defined by normal thyroxin (T4) but abnormal thyroid-stimulating hormone (TSH) levels, may be associated with cardiovascular and metabolic risk. More recently, TSH levels within the normal range have been suggested to be associated with metabolic syndrome and cardiovascular risk. This work studies the linearity of the relationship between metabolic syndrome and TSH across the euthyroid range. Methods and results: We studied 3533 male participants of the Aragon Workers' Health Study (AWHS) with normal TSH and free T4 levels, across quintiles of these variables, after adjusting for age, alcohol intake, and smoking. Compared with the lowest TSH quintile, the odds ratios for metabolic syndrome at the higher quintiles, which indicate lower thyroid function, were 1.34 (1.04, 1.73), 1.56 (1.21, 2.01), 1.57 (1.22, 2.03), and 1.71 (1.32, 2.21). The lowest free T4 quintile also showed an odds ratio of 1.49 (1.16, 1.90) with respect to the highest quintile. In addition, spline models showed departures from linearity: the risk of metabolic syndrome mostly increases at TSH values below the median (sample half-closest to subclinical hyperthyroidism). Interestingly, glucose also increases with TSH primarily below the median TSH, diastolic blood pressure shows similar changes across the entire TSH range, whereas body mass index, triglycerides, and high-density lipoprotein (HDL)-cholesterol change only at the highest normal TSH values, which are associated with lower free T4 concentration. Conclusions: TSH and free T4 within the normal range are associated with the metabolic syndrome. The sample half-below the TSH median (with probably higher functional thyroid status) exhibited better metabolic and cardiovascular profiles.
710			_9625 _aInstituto de Investigación imas12
856			_uhttp://pc-h12o-es.m-hdoct.a17.csinet.es/pdf/pc/1/pc17135.pdf _ySolicitar documento
942			_2ddc _cART _n0