| 000 | nab a22 7a 4500 | ||
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_c17074 _d17074 |
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| 003 | PC17074 | ||
| 005 | 20221117134412.0 | ||
| 008 | 221117b xxu||||| |||| 00| 0 eng d | ||
| 040 | _cH12O | ||
| 041 | _aeng | ||
| 100 |
_93113 _aVillegas, María Rocío _eInstituto de Investigación imas12 |
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_92995 _aBaeza, Alejandro _eInstituto de Investigación imas12 |
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| 245 | 0 | 0 |
_aHybrid Collagenase Nanocapsules for Enhanced Nanocarrier Penetration in Tumoral Tissues. ACS Appl Mater Interfaces. _h[artículo] |
| 260 |
_bACS applied materials & interfaces, _c2015 |
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| 300 | _a7(43):24075-81. | ||
| 500 | _aFormato Vancouver: Villegas MR, Baeza A, Vallet Regí M. Hybrid Collagenase Nanocapsules for Enhanced Nanocarrier Penetration in Tumoral Tissues. ACS Appl Mater Interfaces. 2015 Nov 4;7(43):24075-81. | ||
| 501 | _a PMID: 26461206 | ||
| 504 | _aContiene 26 referencias | ||
| 520 | _aPoor penetration of drug delivery nanocarriers within dense extracellular matrices constitutes one of the main liabilities of current nanomedicines. The conjugation of proteolytic enzymes on the nanoparticle surface constitutes an attractive alternative. However, the scarce resistance of these enzymes against the action of proteases or other aggressive agents present in the bloodstream strongly limits their application. Herein, a novel nanodevice able to transport proteolytic enzymes coated with an engineered pH-responsive polymeric is presented. This degradable coat protects the housed enzymes against proteolytic attack at the same time that it triggers their release under mild acidic conditions, usually present in many tumoral tissues. These enzyme nanocapsules have been attached on the surface of mesoporous silica nanoparticles, as nanocarrier model, showing a significatively higher penetration of the nanoparticles within 3D collagen matrices which housed human osteosarcoma cells (HOS). This strategy can improve the therapeutic efficacy of the current nanomedicines, allowing a more homogeneous and deeper distribution of the therapeutic nanosystems in cancerous tissues. | ||
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_9625 _aInstituto de Investigación imas12 |
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_uhttp://pc-h12o-es.m-hdoct.a17.csinet.es/pdf/pc/1/pc17074.pdf _ySolicitar documento |
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_2ddc _cART _n0 |
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