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999			_c17037 _d17037
003			PC17037
005			20221027095652.0
008			221026b xxu||||| |||| 00| 0 eng d
040			_cH12O
041			_aeng
100			_92167 _aRuiz Hurtado, Gema _eInstituto de Investigación i+12
245	0	0	_aGenetic predisposition to albuminuria is associated with increased arterial stiffness: role of elastin. _h[artículo]
260			_bBritish journal of pharmacology, _c2015
300			_a172(17):4406-18.
500			_aFormato Vancouver: Gil Ortega M, García Prieto CF, Ruiz Hurtado G, Steireif C, González MC, Schulz A et al. Genetic predisposition to albuminuria is associated with increased arterial stiffness: role of elastin. Br J Pharmacol. 2015 Sep;172(17):4406-18.
501			_aPMID: 26075500 PMC4556477
504			_aContiene 62 referencias
520			_aBackground and purpose: The Munich Wistar Frömter (MWF) rat strain represents an experimental model to study cardiovascular alterations under conditions of progressive albuminuria. The aim of this study was to evaluate the association between genetic predisposition to albuminuria and the development of arterial stiffness and/or vascular remodelling. Experimental approach: Experiments were performed in mesenteric arteries from 12-week-old MWF, Wistar Kyoto (WKY) and consomic MWF-6(SHR) and MWF-8(SHR) rats in which chromosomes 6 or 8 associated with albuminuria from MWF were replaced by the respective chromosome from spontaneously hypertensive rats (SHR). Key results: Incremental distensibility, wall stress and strain were reduced, and arterial stiffness was significantly increased in albuminuric MWF compared with WKY. Albuminuria suppression in both consomic strains was associated with lower β-values in MWF-8(SHR) and MWF-6(SHR) compared with MWF. Moreover, elastin content was significantly lower in MWF external elastic lamina compared with WKY and both consomic strains. In addition, a reduction in arterial external and internal diameter and cross-sectional area was detected in MWF compared with WKY, thus exhibiting an inward hypotrophic remodelling. However, these alterations remained unchanged in both consomic strains. Conclusion and implications: These data demonstrate that albuminuria in MWF is associated with increased arterial stiffness due to a reduction of elastin content in the external elastic lamina. Moreover, inward hypotrophic remodelling in MWF is not directly associated with albuminuria. In contrast, we demonstrated that two major genetic loci affect both the development of albuminuria and arterial stiffness, thus linking albuminuria and impairment of mechanical properties of resistance arteries.
710			_9625 _aInstituto de Investigación imas12
856			_uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC4556477/ _yAcceso libre
942			_2ddc _cART _n0