000			nab a22 7a 4500
999			_c16937 _d16937
003			PC16937
005			20220708120758.0
008			220708b xxu||||| |||| 00| 0 eng d
040			_cH12O
041			_aeng
100			_983 _aMorales Ruiz, Enrique _eNefrología
100			_9286 _aCaro Espada, Paula Jara _eNefrología
100			_9417 _aGutiérrez Martínez, Eduardo _eNefrología
100			_9285 _aSevillano Prieto, Ángel Manuel _eNefrología
100			_92305 _aAuñón Rubio, Pilar _eNefrología
100			_91488 _aPraga Terente, Manuel _eNefrología
245	0	0	_aDiverse diuretics regimens differentially enhance the antialbuminuric effect of renin-angiotensin blockers in patients with chronic kidney disease. _h[artículo]
260			_bKidney international, _c2015
300			_a88(6):1434-1441.
500			_aFormato Vancouver: Morales E, Caro J, Gutiérrez E, Sevillano A, Auñón P, Fernandez C et al. Diverse diuretics regimens differentially enhance the antialbuminuric effect of renin-angiotensin blockers in patients with chronic kidney disease. Kidney Int. 2015 Dec;88(6):1434-1441.
501			_aPMID: 26308670
504			_aContiene 38 referencias
520			_aThe addition of spironolactone or hydrochlorothiazide enhances the antialbuminuric effect of renin-angiotensin blockers. However, comparative studies on the effect of different diuretics are lacking. We conducted a prospective randomized crossover study to compare the effects of spironolactone (25 mg/day), hydrochlorothiazide (50 mg/day) without/with amiloride (5 mg/day) on top of enalapril treatment in 21 patients with CKD stages 1-3 and a urinary albumin-to-creatinine ratio (UACR) over 300 mg/g. Treatment periods lasted 4 weeks. The UACR showed a significant reduction with the diuretics: spironolactone, -34% or hydrochlorothiazide without/with amiloride -42% or -56%, respectively. Reduction of the UACR was significantly greater with hydrochlorothiazide without/with amiloride when compared with spironolactone. The percentage of patients who achieved UACR reductions greater than 30% and 50% was greater with hydrochlorothiazide without/with amiloride (81% and 57%, and 81% and 66%, respectively) when compared with spironolactone alone (57% and 28%, respectively). Glomerular filtration rate (GFR), blood pressure, and body weight decreased with the three diuretic regimens. A significant correlation was found between the UACR reduction and GFR and blood pressure changes. Thus, diverse diuretic regimens differentially enhance albuminuria reduction, an effect likely associated with the degree of GFR reduction.
710			_986 _aServicio de Nefrología
856			_uhttp://pc-h12o-es.m-hdoct.a17.csinet.es/pdf/pc/1/pc16937.pdf _ySolicitar documento
942			_2ddc _cART _n0