000			nab a22 7a 4500
999			_c16817 _d16817
003			PC16817
005			20220425121045.0
008			220425b xxu||||| |||| 00| 0 eng d
040			_cH12O
041			_aeng
100			_93030 _aPérez Gil, Jesús _eInstituto de Investigación imas12
245	0	0	_aBio-inspired materials in drug delivery: Exploring the role of pulmonary surfactant in siRNA inhalation therapy. _h[revisión]
260			_bJournal of controlled release : official journal of the Controlled Release Society, _c2015
300			_a220(Pt B):642-50.
500			_aFormato Vancouver: De Backer L, Cerrada A, Pérez Gil J, De Smedt SC, Raemdonck K. Bio-inspired materials in drug delivery: Exploring the role of pulmonary surfactant in siRNA inhalation therapy. J Control Release. 2015 Dec 28;220(Pt B):642-50.
501			_aPMID: 26363301
504			_aContiene 105 referencias
520			_aMany pathologies of the respiratory tract are inadequately treated with existing small molecule-based therapies. The emergence of RNA interference (RNAi) enables the post-transcriptional silencing of key molecular disease factors that cannot readily be targeted with conventional small molecule drugs. Pulmonary administration of RNAi effectors, such as small interfering RNA (siRNA), allows direct delivery into the lung tissue, hence reducing systemic exposure. Unfortunately, the clinical translation of RNAi is severely hampered by inefficient delivery of siRNA therapeutics towards the cytoplasm of the target cells. In order to have a better control of the siRNA delivery process, both extra- and intracellular, siRNAs are typically formulated in nanosized delivery vehicles (nanoparticles, NPs). In the lower airways, which are the targeted sites of action for multiple pulmonary disorders, these siRNA-loaded NPs will encounter the pulmonary surfactant (PS) layer, covering the entire alveolar surface. The interaction between the instilled siRNA-loaded NPs and the PS at this nano-bio interface results in the adsorption of PS components onto the surface of the NPs. The formation of this so-called biomolecular corona conceals the original NP surface and will therefore profoundly determine the biological efficacy of the NP. Though this interplay has initially been regarded as a barrier towards efficient siRNA delivery to the respiratory target cell, recent reports have illustrated that the interaction with PS might also be beneficial for local pulmonary siRNA delivery.
710			_9625 _aInstituto de Investigación imas12
856			_uhttp://pc-h12o-es.m-hdoct.a17.csinet.es/pdf/pc/1/pc16817.pdf _ySolicitar documento
942			_2ddc _cREV _n0