000			nab a22 7a 4500
999			_c16715 _d16715
003			PC16715
005			20220202130759.0
008			220202b xxu||||| |||| 00| 0 eng d
040			_cH12O
041			_aeng
100			_91219 _aRodríguez Peralto, José Luis _eAnatomía Patológica
245	0	0	_aWhole-exome sequencing in splenic marginal zone lymphoma reveals mutations in genes involved in marginal zone differentiation. _h[artículo]
260			_bLeukemia, _c2014
300			_a28(6):1334-40.
500			_aFormato Vancouver: Martínez N, Almaraz C, Vaqué JP, Varela I, Derdak S, Beltran S et al. Whole-exome sequencing in splenic marginal zone lymphoma reveals mutations in genes involved in marginal zone differentiation. Leukemia. 2014 Jun;28(6):1334-40.
501			_aPMID: 24296945
504			_aContiene 49 referencias
520			_aSplenic marginal zone lymphoma (SMZL) is a B-cell neoplasm whose molecular pathogenesis remains fundamentally unexplained, requiring more precise diagnostic markers. Previous molecular studies have revealed 7q loss and mutations of nuclear factor κB (NF-κB), B-cell receptor (BCR) and Notch signalling genes. We performed whole-exome sequencing in a series of SMZL cases. Results confirmed that SMZL is an entity distinct from other low-grade B-cell lymphomas, and identified mutations in multiple genes involved in marginal zone development, and others involved in NF-κB, BCR, chromatin remodelling and the cytoskeleton.
710			_9330 _aServicio de Anatomía Patológica
856			_uhttp://pc-h12o-es.m-hdoct.a17.csinet.es/pdf/pc/1/pc16715.pdf _ySolicitar documento
942			_2ddc _cART _n0