000			nab a22 7a 4500
999			_c16660 _d16660
003			PC16660
005			20211116133948.0
008			211116b xxu||||| |||| 00| 0 eng d
040			_cH12O
041			_aeng
100			_91883 _aUsátegui Corral, Alicia _eInstituto de Investigación i+12
100			_91880 _aCriado Carrasco, Gabriel _eInstituto de Investigación i+12
100			_91881 _aRey Cerros, Manuel José del _eInstituto de Investigación i+12
100			_92671 _aFaré García, Regina _eInstituto de Investigación i+12
100			_91010 _aPablos Álvarez, José Luis _eReumatología
245	0	0	_aTopical vitamin D analogue calcipotriol reduces skin fibrosis in experimental scleroderma. _h[artículo]
260			_bArchives of dermatological research, _c2014
300			_a306(8):757-61.
500			_aFormato Vancouver: Usategui A, Criado G, Del Rey MJ, Faré R, Pablos JL. Topical vitamin D analogue calcipotriol reduces skin fibrosis in experimental scleroderma. Arch Dermatol Res. 2014 Oct;306(8):757-61.
501			_aPMID: 24788893
504			_aContiene 21 referencias
520			_aVitamin D analogues can reduce TGF-β pro-fibrotic signaling in dermal fibroblasts, but they may also induce a potentially pro-fibrotic thymic stromal lymphopoietin (TSLP)-dependent Th2 cytokine local response. We have analyzed the net effect of topical vitamin D analogue calcipotriol (CPT) on the cytokine profile and the development of fibrosis in experimental model of bleomycin-induced fibrosis. Mice were simultaneously treated with topical CPT or vehicle cream and skin fibrosis was measured by collagen deposition, Masson's trichrome staining and hydroxyproline content. Cytokine and TSLP gene expression was evaluated by quantitative RT-PCR. We showed that in bleomycin injected skin, CPT administration significantly enhanced TSLP and IL-13 gene expression, but did not modify the expression of other cytokines. Skin fibrosis and hydroxyproline content were significantly reduced in CPT compared to vehicle-treated mice. In normal skin, topical administration of CPT lacked a direct pro-fibrotic effect. Our results demonstrate that topical CPT superinduces the expression of the TSLP/IL-13 Th2 axis in fibrotic skin, but it has a net anti-fibrotic effect. These data support the therapeutic use of topical vitamin D analogues for skin fibrosis.
710			_9123 _aServicio de Reumatología
710			_9625 _aInstituto de Investigación imas12
856			_uhttp://pc-h12o-es.m-hdoct.a17.csinet.es/pdf/pc/1/pc16660.pdf _ySolicitar documento
942			_2ddc _cART _n0