000 | nab a22 7a 4500 | ||
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999 |
_c16594 _d16594 |
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003 | PC16594 | ||
005 | 20211005132226.0 | ||
008 | 210827b xxu||||| |||| 00| 0 eng d | ||
040 | _cH12O | ||
041 | _aeng | ||
100 |
_9882 _aCastellano, Daniel _eOncología Médica |
||
245 | 0 | 0 |
_aSafety and effectiveness of vinflunine in patients with metastatic transitional cell carcinoma of the urothelial tract after failure of one platinum-based systemic therapy in clinical practice _h[artículo] |
260 |
_bBMC cancer, _c2014 |
||
300 | _a14:779. | ||
500 | _aFormato Vancouver: Castellano D, Puente J, de Velasco G, Chirivella I, López Criado P, Mohedano N et al. Safety and effectiveness of vinflunine in patients with metastatic transitional cell carcinoma of the urothelial tract after failure of one platinum-based systemic therapy in clinical practice. BMC Cancer. 2014 Oct 24;14:779. | ||
501 | _aPMID: 25342282 PMC4216839 | ||
504 | _aContiene 40 referencias | ||
520 | _aBackground: Patients with transitional cell carcinoma of the urothelial tract (TCCU) who fail initial platinum-based chemotherapy for advanced disease represent a challenge in daily clinical practice. Vinflunine is approved by the European Medicine Agency (EMA) but, up to now, limited experience has been reported outside clinical trials. Methods: We assessed the efficacy and safety of vinflunine in an unselected group of 102 consecutive patients with metastatic TCCU. Results: The median age was 67 years (range 45-83). Among the most common comorbidities that patients presented at baseline were hypertension (50.5%) and diabetes (20.7%).Distant metastases were present in retroperitoneal nodes (58%), lung (29.3%), and bone (20.2%). The ECOG 0, 1 and 2 performance status at the start of vinflunine were 31.3%, 60.6% and 8.1%, respectively. The most commonly reported adverse events of any grade were constipation 70.6% (5.9% grade 3-4), vomiting 49.1% (2% grade 3-4), neutropenia 48.1% (12.8% grade 3-4) and abdominal pain 34.3% (4.9% grade 3-4). A median of 4 cycles of vinflunine was administered per patient (range 1-18). Median progression free and overall survival for all patients (N = 102) were 3.9 months (2.3-5.5) and 10 months (7.3-12.8), respectively. Time to tumor progression was 4.3 months (2.6-5.9). Two patients (2%) achieved CR, 23 (22.5%) patients had PR, and 42 (41.2%) presented SD as best response. The clinical benefit rate with vinflunine was 65.7%. Conclusions: Our results show that the behavior of vinflunine in routine clinical practice resembles that of the pivotal phase III randomized study. | ||
710 |
_9303 _aServicio de Oncología Médica |
||
856 |
_uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC4216839/ _yAcceso libre |
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942 |
_2ddc _cART _n0 |