000			nab a22 7a 4500
999			_c16376 _d16376
003			PC16376
005			20210625062821.0
008			210429b xxu||||| |||| 00| 0 eng d
040			_cH12O
041			_aeng
100			_92408 _aCuartero, María Isabel _eInstituto de Investigación i+12
100			_92407 _aBallesteros, Iván _eInstituto de Investigación i+12
100			_92410 _aLizasoain, Ignacio _eInstituto de Investigación i+12
100			_92826 _aDe la Parra, Juan _eInstituto de Investigación i+12
245	0	0	_a L-kynurenine/aryl hydrocarbon receptor pathway mediates brain damage after experimental stroke. _h[artículo]
260			_bCiruculation, _c2014
300			_a130(23):2040-51.
500			_aFormato Vancouver: Cuartero MI, Ballesteros I, de la Parra J, Harkin AL, Abautret-Daly A, Sherwin et al. L-kynurenine/aryl hydrocarbon receptor pathway mediates brain damage after experimental stroke. Circulation. 2014 Dec 2;130(23):2040-51.
501			_aPMID: 25359166
504			_aContiene 44 referencias
520			_aBackground: Aryl hydrocarbon receptor (AhR) is a transcription factor that belongs to the basic helix-loop-helix PAS (Per-Arnt-Sim homology domain) family known to mediate the toxic and carcinogenic effects of xenobiotics. Interestingly, AhR is widely expressed in the central nervous system, but its physiological and pathological roles are still unclear. Methods and results: To define the role of AhR in stroke, we used middle cerebral artery occlusion in mice and oxygen-glucose deprivation in rat cortical neurons. The results presented here show that the ischemic insult increases total and nuclear AhR levels and AhR transcriptional activity in neurons in vivo and in vitro. We also show that AhR has a causal role in acute ischemic damage because pharmacological or genetic loss-of-function approaches result in neuroprotection. Inhibition of cAMP response element-binding protein-dependent signaling may participate in the deleterious actions of AhR. Finally, we have also found that L-kynurenine, a tryptophan metabolite with AhR agonistic properties, is an endogenous ligand that mediates AhR activation in the brain after middle cerebral artery occlusion. Conclusions: Our data demonstrate that an L-kynurenine/AhR pathway mediates acute brain damage after stroke and open new possibilities for the diagnosis and treatment of this pathology.
710			_9625 _aInstituto de Investigación imas12
856			_uhttp://pc-h12o-es.m-hdoct.a17.csinet.es/pdf/pc/1/pc16376.pdf _ySolicitar documento
942			_2ddc _cART _n0