000			nab a22 7a 4500
999			_c16374 _d16374
003			PC16374
005			20210625062821.0
008			210428b xxu||||| |||| 00| 0 eng d
040			_cH12O
041			_aeng
100			_9263 _aFernández Ruiz, Mario _eMedicina Interna
100			_9162 _aLópez Medrano, Francisco _eEnfermedades Infecciosas
100			_91508 _aAllende Martínez, Luis Miguel _eInmunología
100			_91321 _aAndrés Belmonte, Amado _eNefrología
100			_91210 _aGarcía Reyne, Ana _eMedicina Interna
100			_9873 _aLumbreras Bermejo, Carlos _eMedicina Interna
100			_9869 _aSan Juan Garrido, Rafael _eMedicina Interna
100			_9576 _aMorales Cerdán, José María _eNefrología
100			_91510 _aPaz Artal, Estela _eInmunología
100			_9876 _aAguado García, José María _eEnfermedades Infecciosas
245	0	0	_aKinetics of peripheral blood lymphocyte subpopulations predicts the occurrence of opportunistic infection after kidney transplantation. _h[artículo]
260			_bTransplant international : official journal of the European Society for Organ Transplantation, _c2014
300			_a27(7):674-85.
500			_aFormato Vancouver: Fernández-Ruiz M, López-Medrano F, Allende LM, Andrés A, García-Reyne A, Lumbreras C et al. Kinetics of peripheral blood lymphocyte subpopulations predicts the occurrence of opportunistic infection after kidney transplantation. Transpl Int. 2014 Jul;27(7):674-85.
501			_aPMID: 24650360
504			_aContiene 44 referencias
520			_aSerial monitoring of peripheral blood lymphocyte subpopulations (PBLSs) counts might be useful in predicting post-transplant opportunistic infection (OI) after kidney transplantation (KT). PBLSs were prospectively measured in 304 KT recipients at baseline and post-transplant months 1 and 6. Areas under receiver operating characteristic curves were used to evaluate the accuracy of different subpopulations in predicting the occurrence of overall OI and, specifically, cytomegalovirus (CMV) disease. We separately analyzed patients not receiving (n = 164) or receiving (n = 140) antithymocyte globulin (ATG) as induction therapy. In the non-ATG group, a CD8(+) T-cell count at month 1 <0.100 × 10(3) cells/μl had negative predictive values of 0.84 and 0.86 for the subsequent occurrence of overall OI and CMV disease, respectively. In the multivariate Cox model, a CD8(+) T-cell count <0.100 × 10(3) cells/μl was an independent risk factor for OI (adjusted hazard ratio: 3.55; P-value = 0.002). In the ATG group, a CD4(+) T-cell count at month 1 <0.050 × 10(3) cells/μl showed negative predictive values of 0.92 for the subsequent occurrence of overall OI and CMV disease. PBLSs monitoring effectively identify KT recipients at low risk of OI, providing an opportunity for individualizing post-transplant prophylaxis practices.
710			_96 _aServicio de Medicina Interna
710			_9395 _aServicio de Inmunología
710			_986 _aServicio de Nefrología
710			_9625 _aInstituto de Investigación imas12
856			_uhttp://pc-h12o-es.m-hdoct.a17.csinet.es/pdf/pc/1/pc16374.pdf _ySolicitar documento
942			_2ddc _cART _n0