000			nab a22 7a 4500
999			_c16363 _d16363
003			PC16363
005			20210625062821.0
008			210421b xxu||||| |||| 00| 0 eng d
040			_cH12O
041			_aeng
100			_9263 _aFernández Ruiz, Mario _eMedicina Interna
100			_9876 _aAguado García, José María _eEnfermedades Infecciosas
100			_9821 _aLora Pablos, David _eInstituto Investigación I+12
245	0	0	_aInitial use of echinocandins does not negatively influence outcome in Candida parapsilosis bloodstream infection: a propensity score analysis. _h[artículo]
260			_bClinical infectious diseases : an official publication of the Infectious Diseases Society of America, _c2014
300			_a58(10):1413-21.
500			_aFormato Vancouver: Fernández-Ruiz M, Aguado JM, Almirante B, Lora-Pablos D, Padilla B, Puig-Asensio M et al; CANDIPOP Project; GEIH-GEMICOMED (SEIMC); REIPI. Initial use of echinocandins does not negatively influence outcome in Candida parapsilosis bloodstream infection: a propensity score analysis. Clin Infect Dis. 2014 May;58(10):1413-21.
501			_aPMID: 24642553
504			_aContiene 40 referencias
520			_aBackground: Concerns have arisen regarding the optimal antifungal regimen for Candida parapsilosis bloodstream infection (BSI) in view of its reduced susceptibility to echinocandins. Methods: The Prospective Population Study on Candidemia in Spain (CANDIPOP) is a prospective multicenter, population-based surveillance program on Candida BSI conducted through a 12-month period in 29 Spanish hospitals. Clinical isolates were identified by DNA sequencing, and antifungal susceptibility testing was performed by the European Committee on Antimicrobial Susceptibility Testing methodology. Predictors for clinical failure (all-cause mortality between days 3 to 30, or persistent candidemia for ≥72 hours after initiation of therapy) in episodes of C. parapsilosis species complex BSI were assessed by logistic regression analysis. We further analyzed the impact of echinocandin-based regimen as the initial antifungal therapy (within the first 72 hours) by using a propensity score approach. Results: Among 752 episodes of Candida BSI identified, 200 (26.6%) were due to C. parapsilosis species complex. We finally analyzed 194 episodes occurring in 190 patients. Clinical failure occurred in 58 of 177 (32.8%) of evaluable episodes. Orotracheal intubation (adjusted odds ratio [AOR], 2.81; P = .018) and septic shock (AOR, 2.91; P = .081) emerged as risk factors for clinical failure, whereas early central venous catheter removal was protective (AOR, 0.43; P = .040). Neither univariate nor multivariate analysis revealed that the initial use of an echinocandin-based regimen had any impact on the risk of clinical failure. Incorporation of the propensity score into the model did not change this finding. Conclusions: The initial use of an echinocandin-based regimen does not seem to negatively influence outcome in C. parapsilosis BSI.
710			_96 _aServicio de Medicina Interna
710			_9625 _aInstituto de Investigación imas12
856			_uhttp://pc-h12o-es.m-hdoct.a17.csinet.es/pdf/pc/1/pc16363.pdf _ySolicitar documento
942			_2ddc _cART _n0