000			nab a22 7a 4500
999			_c16319 _d16319
003			PC16319
005			20210625062820.0
008			210316b xxu||||| |||| 00| 0 eng d
040			_cH12O
041			_aeng
100			_91510 _aPaz Artal, Estela _eInmunología
100			_91511 _aTalayero Giménez de Azcárate, Paloma _eInmunología
100			_9576 _aMorales Cerdán, José María _eNefrología
245	0	0	_aHigh proportion of pretransplantation activated regulatory T cells CD4+CD25highCD62L+CD45RO+) predicts acute rejection in kidney transplantation: results of a multicenter study. _h[artículo]
260			_bTransplantation, _c2014
300			_a98(11):1213-8.
500			_aFormato Vancouver: San Segundo D, Millán O, Muñoz-Cacho P, Boix F, Paz-Artal E, Talayero P et al. High proportion of pretransplantation activated regulatory T cells CD4+CD25highCD62L+CD45RO+) predicts acute rejection in kidney transplantation: results of a multicenter study. Transplantation. 2014 Dec 15;98(11):1213-8.
501			_aPMID: 25083613
504			_aContiene 26 referencias
520			_aBackground: Prognostic biomarkers of acute rejection (AR) in solid organ transplantation have been addressed in multiple small retrospective studies, and there is a critical need for multicenter studies. Because of their tolerogenic properties, regulatory T cells (Tregs) play an important role in transplant outcome. Methods: In the present multicenter study, we have retrospectively examined different Treg subpopulations in an independent cohort of kidney transplant patients within first year after kidney transplantation. All participating centers used identical flow cytometry standard operating procedures. Results: Seventy-five renal transplant patients were included, and six of them experienced an AR episode. The activated Treg (aTreg) subpopulation (CD4CD25CD62LCD45RO) was increased in the AR group before transplantation, and an aTreg percentage higher than 1.46% before kidney transplantation conferred an increased risk of AR. The univariate logistic regression model achieved an area under the curve of 81.6%. By including recipient age and thymoglobulin induction as variables in a multivariate logistic regression model, the prediction of AR improved to 92.4%. Conclusion: The evaluation of CD4CD25CD62LCD45RO aTreg cells may be useful as pretransplantation predictive biomarker of AR in kidney transplant patients. Definitive confirmation of our results awaits tests in validation groups.
710			_9395 _aServicio de Inmunología
710			_986 _aServicio de Nefrología
710			_9625 _aInstituto de Investigación imas12
856			_uhttp://pc-h12o-es.m-hdoct.a17.csinet.es/pdf/pc/1/pc16319.pdf _ySolicitar documento
942			_2ddc _cART _n0