| 000 | 02338na a2200253 4500 | ||
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| 003 | PC13966 | ||
| 005 | 20210625062812.0 | ||
| 008 | 130622s2013 xxx||||| |||| 00| 0 eng d | ||
| 040 | _cH12O | ||
| 041 | _aeng | ||
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_aAntequera, Desiree _92134 _eInstituto de Investigación i+12 |
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_aBolos, Marta _92135 _eInstituto de Investigación i+12 |
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_aCarro Díaz, Eva _91777 _eInstituto de Investigación i+12 |
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| 245 | 0 | 0 |
_aChoroid plexus implants rescue Alzheimer's disease-like pathologies by modulating amyloid-β degradation. _h[artículo] |
| 260 |
_bCellular and molecular life sciences: CMLS, _c2013 |
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| 300 | _a71(15):2947-55. | ||
| 500 | _aFormato Vancouver: Bolos M, Antequera D, Aldudo J, Kristen H, Bullido MJ, Carro E. Choroid plexus implants rescue Alzheimer's disease-like pathologies by modulating amyloid-β degradation. Cell Mol Life Sci. 2014 Aug;71(15):2947-55. | ||
| 501 | _aPMID: 24343520 | ||
| 504 | _aContiene 43 referencias | ||
| 520 | _aThe choroid plexuses (CP) release numerous biologically active enzymes and neurotrophic factors, and contain a subpopulation of neural progenitor cells providing the capacity to proliferate and differentiate into other types of cells. These characteristics make CP epithelial cells (CPECs) excellent candidates for cell therapy aiming at restoring brain tissue in neurodegenerative illnesses, including Alzheimer's disease (AD). In the present study, using in vitro approaches, we demonstrated that CP were able to diminish amyloid-β (Aβ) levels in cell cultures, reducing Aβ-induced neurotoxicity. For in vivo studies, CPECs were transplanted into the brain of the APP/PS1 murine model of AD that exhibits advanced Aβ accumulation and memory impairment. Brain examination after cell implantation revealed a significant reduction in brain Aβ deposits, hyperphosphorylation of tau, and astrocytic reactivity. Remarkably, the transplantation of CPECs was accompanied by a total behavioral recovery in APP/PS1 mice, improving spatial and non-spatial memory. These findings reinforce the neuroprotective potential of CPECs and the use of cell therapies as useful tools in AD. | ||
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_9625 _aInstituto de Investigación imas12 |
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_uhttp://pc-h12o-es.m-hdoct.a17.csinet.es/pdf/pc/1/pc13966.pdf _ySolicitar documento |
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_n0 _2ddc _cART |
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_c13966 _d13966 |
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