000			02763na a2200289 4500
003			PC1342
005			20210625062756.0
008			130622s2013
040			_cH12O
041			_aeng
100			_aAllo, Gonzalo _9761 _eEndocrinología y Nutrición
100			_9763 _aEnríquez de Salamanca Lorente, Rafael _eInstituto de Investigación i+12 _d(2013-)
100			_aMartínez Díaz-Guerra, Guillermo _9760 _eEndocrinología y Nutrición
100			_9501 _aHawkins Carranza, Federico Gustavo _eEndocrinología y Nutrición
100			_aMartínez, Guillermo
245	0	0	_aBone mineral density and vitamin D levels in erythropoietic protoporphyria _h[artículo]
260			_aEndocrine, _c2013.
300			_a44(3):803-807.
500			_aFormato Vancouver: Allo G, Garrido Astray MC, Enríquez de Salamanca R, Martínez G, Hawkins F. Bone mineral density and vitamin D levels in erythropoietic protoporphyria. Endocrine. 2013;44(3):803-7.
501			_aPMID:23536284
504			_aContiene 21 referencias y 2 tablas.
520			_aResumen: Erythropoietic protoporphyria (EPP) is a rare disease with painful cutaneous photosensitivity, in which patients are recommended to avoid sun exposure, and wear sunscreen and adequate clothing. Our aim was to study bone mineral density (BMD) and other mineral parameters, including serum 25(OH)D levels, to evaluate the impact of these measures in the follow-up of EPP patients. A cross-sectional study of ten EPP patients (median age 25; range 22-55, four males and six females), was performed evaluating clinical features, biochemical values (bone markers and serum 25 hydroxyvitamin D), and BMD. Median serum 25(OH)D level was 19.65 ng/ml [17.50; 24.80]. Four patients had 25(OH)D in insufficiency range (20-30 ng/ml) and five patients in the deficiency range (<20 ng/ml). Lumbar T-score median levels were in the osteopenia range in both females (-1.50 [-2.30; -1.0]) and males (-1.90 [-2.40; -0.70]). Also, in the female group median femoral neck T-score were in the osteopenia range (-1.20 [-1.60; -0.60]). This is the first study reporting low BMD in EPP patients. Osteoporosis, osteopenia, and vitamin D deficiency are frequent findings in EPP patients. The contribution of sunlight avoidance measures to these results remains to be clarified. Serum levels of protoporphyrins were not related to these alterations and other factors should be investigated. We suggest that the monitoring of serum vitamin D levels in EPP patients should be mandatory, as well as vitamin D and calcium supplementation.
710			_9292 _aServicio de Endocrinología y Nutrición
710			_9625 _aInstituto de Investigación imas12
856			_uhttp://pc-h12o-es.m-hdoct.a17.csinet.es/pdf/pc1342.pdf _ySolicitar documento
942			_2ddc _cART _n0
999			_c1342 _d1342