000			03135na a2200517 4500
999			_c13361 _d13361
003			PC13361
005			20191205062648.0
008			130622s2013 xxx||||| |||| 00| 0 eng d
040			_cH12O
041			_aeng
100			_aBenito León, Julián _9892 _eNeurología
100			_aBermejo Pareja, Félix _9582 _eNeurología
100			_aMoreno Garcia, Sara _92613 _eNeurología
100			_92071 _aRomero Muñoz, Juan Pablo _eInstituto de Investigación i+12
245	0	0	_aBlood harmane (1-methyl-9H-pyrido[3,4-b]indole) concentration in essential tremor cases in Spain. _h[artículo]
260			_bNeurotoxicology, _c2013
300			_a34:264-8.
500			_aFormato Vancouver: Louis ED, Benito-León J, Moreno-García S, Vega S, Romero JP, Bermejo-Pareja F, et al. Blood harmane (1-methyl-9H-pyrido[3,4-b]indole) concentration in essential tremor cases in Spain. Neurotoxicology. 2013 Jan;34:264-8.
501			_aPMID: 22981972
504			_aContiene 33 referencias
520			_aEnvironmental correlates for essential tremor (ET) are largely unexplored. The search for such environmental factors has involved the study of a number of neurotoxins. Harmane (1-methyl-9H-pyrido[3,4-b]indole) is a potent tremor-producing toxin. In two prior case-control studies in New York, we demonstrated that blood harmane concentration was elevated in ET patients vs. controls, and especially in familial ET cases. These findings, however, have been derived from a study of cases ascertained through a single tertiary referral center in New York. Objective: Our objective was to determine whether blood harmane concentrations are elevated in familial and sporadic ET cases, ascertained from central Spain, compared to controls without ET. Methods: Blood harmane concentrations were quantified by a well-established high performance liquid chromatography method. Results: The median harmane concentrations were: 2.09 g(-10)/ml (138 controls), 2.41 g(-10)/ml (68 sporadic ET), and 2.90 g(-10)/ml (62 familial ET). In an unadjusted logistic regression analysis, log blood harmane concentration was not significantly associated with diagnosis (familial ET vs. control): odds ratio = 1.56, p = 0.26. In a logistic regression analysis that adjusted for evaluation start time, which was an important confounding variable, the odds ratio increased to 2.35, p = 0.049. Conclusions: Blood harmane levels were slightly elevated in a group of familial ET cases compared to a group of controls in Spain. These data seem to further extend our observations from New York to a second cohort of ET cases in Spain. This neurotoxin continues to be a source of interest for future confirmatory research.
710			_9267 _aServicio de Neurología-Neurofisiología
856			_uhttp://europepmc.org/backend/ptpmcrender.fcgi?accid=PMC3556362&blobtype=pdf _yAcceso libre
942			_n0 _2ddc _cART