000			00802na a2200253 4500
999			_c12907 _d12907
003			PC12907
005			20200129123652.0
008			130622s2014 xxx||||| |||| 00| 0 eng d
040			_cH12O
041			_aeng
100			_aMoreno González, Enrique _9510 _eCirugía General y del Aparato Digestivo
100			_aIbarrola de Andrés, Carolina _9327 _eAnatomía Patológica
245	0	0	_aMelatonin Treatment Protects Liver of Zucker Rats After Ischemia/Reperfusion by Diminishing Oxidative Stress and Apoptosis _h[artículo]
260			_bEuropean journal of pharmacology, _c2013
300			_a701(1-3):185-93.
500			_aFormato Vancouver: Kireev R, Bitoun S, Cuesta S, Tejerina A, Ibarrola C, Moreno E et al. Melatonin treatment protects liver of Zucker rats after ischemia/reperfusion by diminishing oxidative stress and apoptosis. Eur J Pharmacol. 2013 Feb 15;701(1-3):185-93.
501			_aPMID: 23220161
504			_aContiene 65 referencias
520			_aFatty livers occur in up to 20% of potential liver donors and increase cellular injury during the ischemia/reperfusion phase, so any intervention that could enable a better outcome of grafts for liver transplantation would be very useful. The effect of melatonin on liver ischemia/reperfusion injury in a rat model of obesity and hepatic steatosis has been investigated. Forty fa/fa Zucker rats were divided in 4 groups. 3 groups were subjected to 35 min of warm hepatic ischemia and 36 h of reperfusion. One experimental group remained untreated and 2 were given 10mg/kg melatonin intraperitoneally or orally. Another group was sham-operated. Plasma ALT, AST and hepatic content of ATP, MDA, hydroxyalkenals, NOx metabolites, antioxidant enzyme activity, caspase-9 and DNA fragmentation were determined in the liver. The expression of iNOS, eNOS, Bcl2, Bax, Bad and AIF were determined by RT-PCR Melatonin was effective at decreasing liver injury by both ways as assessed by liver transaminases, markers of apoptosis, of oxidative stress and improved liver ATP content. Melatonin administration decreased the activities or levels of most of the parameters measured in a beneficial way, and our study identified also some of the mechanisms of protection. We conclude that administration of melatonin improved liver function, as well as markers of pro/antioxidant status and apoptosis following ischemia/reperfusion in obese rats with fatty liver. These data suggest that this substance could improve outcome in patients undergoing liver transplantation who receive a fatty liver implant and suggest the need of clinical trials with it in liver transplantation.
710			_9271 _aServicio de Cirugía General y del Aparato Digestivo
710			_9330 _aServicio de Anatomía Patológica
856			_uhttp://pc-h12o-es.m-hdoct.a17.csinet.es/pdf/pc/1/pc12907.pdf _ySolicitar documento
942			_n0 _2ddc _cART