000			nam a22 4500
999			_c12853 _d12853
003			PC12853
005			20210625062812.0
008			130622s2013 xxx||||| |||| 00| 0 eng d
040			_cH12O
041			_aeng
100			_aFlores de la Cal, Ana Isabel _91025 _eInstituto de Investigación i+12
100			_aGrande García, Jesús _91435 _eGinecología y Obstetricia
100			_aGrau Sanz, Montserrat _91105 _eInstituto de Investigación i+12
100			_aVegh Polgary, I. _91103 _eInstituto de Investigación i+12
245	0	0	_aDecidua mesenchymal stem cells migrated toward mammary tumors in vitro and in vivo affecting tumor growth and tumor development. _h[artículo
260			_bCancer gene therapy, _c2013
300			_a20(1):8-16.
500			_aFormato Vancouver: Vegh I, Grau M, Gracia M, Grande J, de la Torre P, Flores AI. Decidua mesenchymal stem cells migrated toward mammary tumors in vitro and in vivo affecting tumor growth and tumor development. Cancer Gene Ther. 2013 Jan;20(1):8-16.
501			_aPMID: 23037810
504			_aContiene 49 referencias
520			_aMesenchymal stem cells (MSCs) have affinity to tumor sites where they home, affecting their biology and growth. Previously, we have isolated mesenchymal cells from the decidua of the human placenta named as decidua-derived MSCs (DMSCs). The aims of the present study were to investigate the migration capacity of DMSCs in vitro, and in vivo in a preclinical model of mammary tumors induced by N-nitroso-N-methylurea (NMU). Additionally, we assessed the safety of DMSC administration in vivo and their effect on tumor growth. In vitro studies showed that DMSCs significantly migrate toward both, healthy human breast tissue and breast adenocarcinoma. Nevertheless, the effect on DMSC migration was significantly higher in the presence of tumor tissue. DMSCs also significantly migrated in vitro in the presence of NMU-mammary tumor homogenate when compared with control media alone. In vivo studies showed both migration and engraftment of DMSCs into NMU-induced tumors. Interestingly, DMSCs showed an inhibitory effect on the growth of primary tumors and in the development of new tumors. DMSCs did not affect the growth of secondary tumors, although secondary tumors appeared 2 weeks later, and the number of secondary tumors was lower in the DMSC-treated rats as compared with vehicle-treated rats. To our knowledge, this is the first report showing placental MSCs effect on tumor growth. In conclusion, DMSCs could serve as a therapeutic agent themselves and as a cellular vehicle of anticancer drugs.
710			_9625 _aInstituto de Investigación imas12
710			_9427 _aServicio de Obstetricia y Ginecología
856			_uhttp://pc-h12o-es.m-hdoct.a17.csinet.es/pdf/pc/1/pc12853.pdf _ySolicitar documento
942			_n0 _2ddc _cART