000			03114na a2200289 4500
003			H12O
005			20210625062811.0
008			130622s2011 xxx||||| |||| 00| 0 eng d
040			_cH12O
041			_aeng
100			_aHoenicka, Janet _91868 _ePsiquiatría
100			_aMartínez Gras, María Isabel _91870 _ePsiquiatría
100			_9653 _aPalomo Álvarez, Tomás _d(1989-2010) _ePsiquiatría
100			_aRodríguez Jiménez, Roberto _91873 _ePsiquiatría
100			_aRubio Valladolid, Gabriel _9726 _ePsiquiatría
245	0	3	_aThe anti-inflammatory prostaglandin 15d-PGJ2 and its nuclear receptor PPARgamma are decreased in schizophrenia _h[artículo]
260			_bSchizophrenia Research, _c2011
300			_a128(1-3):15-22.
500			_aFormato Vancouver: Martínez Gras I, Pérez Nievas BG, García Bueno B, Madrigal JL, Andrés Esteban E, Rodríguez Jiménez R, et al. The anti-inflammatory prostaglandin 15d-PGJ2 and its nuclear receptor PPARgamma are decreased in schizophrenia. Schizophr Res. 2011;128(1-3):15-22.
501			_aPMID: 21334179
504			_aContiene 64 referencias
520			_aA number of findings suggest that inflammation plays a role in the pathophysiology of schizophrenia. Taking into account a physiological balance between pro- and anti-inflammatory mediators, we measured the plasma levels of cyclooxygenase-derived mediators and other key pro- and anti-inflammatory transcription factors in peripheral blood mononuclear cells (PBMC). Forty healthy subjects and 46 treated chronic schizophrenic patients with an acutely exacerbated condition who met DSM-IV criteria were included. COX by-products prostaglandin E2 (PGE2) and 15d-prostaglandin J2 (15d-PGJ2) plasma levels were measured by EIA. Peroxisome proliferator-activated receptor gamma (PPARγ) as well as nuclear factor kappaB (NFκB) activity in nuclear extracts from PBMC and expression of its inhibitory subunit IκBα in cytosolic extracts were determined using ELISA-based kits. Schizophrenic patients showed higher plasma levels of pro-inflammatory PGE2 than age-matched controls (p=0.043). On the contrary, levels of anti-inflammatory 15-d-PGJ2 were lower (p=0.004), correlating with a lower expression of its nuclear target, PPARγ in nuclear extracts from PBMC (p=0.001). Although no changes in NFκB activity were observed between patients and healthy controls, the expression of its inhibitory protein IκBα was lower in the patients compared to the controls (p=0.027). These findings suggest that schizophrenia is associated with a systemic imbalance in the plasma levels of pro-inflammatory/anti-inflammatory prostaglandins in favor of the former. Furthermore, the expression and activity of anti-inflammatory PPARγ are diminished in PBMC, which indicates a state of inflammation and blunted anti-inflammatory counterbalancing mechanisms at systemic level in these patients.
710			_9150 _aServicio de Psiquiatría
710			_9625 _aInstituto de Investigación imas12
856			_uhttp://pc-h12o-es.m-hdoct.a17.csinet.es/pdf/pc/1/pc12461.pdf _ySolicitar documento
942			_n0 _2ddc _cART
999			_c12461 _d12461