| 000 | 02702na a2200457 4500 | ||
|---|---|---|---|
| 999 |
_c1094 _d1094 |
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| 003 | PC1094 | ||
| 005 | 20191107120751.0 | ||
| 008 | 130622s2013 xxx||||| |||| 00| 0 eng d | ||
| 040 | _cH12O | ||
| 041 | _aeng | ||
| 100 |
_aVivanco Martínez, José Luis _9815 _ePediatría |
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| 245 | 0 | 0 |
_aDetection of occult cerebrospinal fluid involvement during maintenance therapy identifies a group of children with acute lymphoblastic leukemia at high risk for relapse. _h[artículo] |
| 260 |
_bAmerican Journal of Hematology, _c2013 |
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| 300 | _a88(5):359-64. | ||
| 500 | _aFormato Vancouver: Martínez-Laperche C, Gómez-García AM, Lassaletta Á, Moscardó C, Vivanco JL,Molina J et al. Detection of occult cerebrospinal fluid involvement during maintenance therapy identifies a group of children with acute lymphoblastic leukemia at high risk for relapse. Am J Hematol. 2013 May;88(5):359-64. | ||
| 501 | _aPMID: 23468276 | ||
| 504 | _aContiene 32 referencias | ||
| 520 | _aWe aimed at assessing the clinical significance of the levels of acute lymphoblastic leukemia (ALL) cells in samples of cerebrospinal fluid (CSF) during therapy. We studied 990 CSF samples from 108 patients, at the time of diagnosis (108) and at each time of intrathecal therapy (882). The proportions of leukemic cells in CSF samples were assessed by flow cytometry (FCM). Patients with central nervous system (CNS) involvement at diagnosis (FCM+) showed predominantly a T-ALL, and higher percentages of known negative prognostic factors: high risk group, higher white blood cell counts, normal karyotype, and the BCR-ABL fusion gene. No differences in relapse free survival (RFS) and overall survival (OS) were observed between FCM+ versus FCM- at diagnosis. Patients with CNS involvement during therapy showed significantly older age, and higher frequencies of T-cell leukemia. We found a significantly higher RFS in patients with FCM+ during therapy. The detection of subclinical CNS disease by FCM during maintenance was associated with significantly lower 3-years RFS and 3-years OS. A sensitive methodology like FCM can be applied for a close follow-up of the levels of ALL in CFS samples, and may identify a group of patients at high risk for relapse. | ||
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_9446 _aServicio de Pediatría-Neonatología |
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_uhttp://pc-h12o-es.m-hdoct.a17.csinet.es/pdf/pc/1/pc1094.pdf _ySolicitar documento |
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| 942 |
_n0 _2ddc _cART |
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