AU - Castellano, Daniel AU - Cortés-Funes Castro, Hernán AU - García Escobar, Ignacio AU - Sepúlveda Sánchez, Juan Manuel AU - Rodríguez Antolín, Alfredo ED - Servicio de Oncología Médica ED - Servicio de Urología TI - The role of RANK-ligand inhibition in cancer: The story of denosumab PY - 2011/// PB - Oncologist N1 - Formato Vancouver: Castellano D, Sepúlveda JM, García Escobar I, Rodriguez Antolín A, Sundlöv A, Cortés-Funes H. The role of RANK-ligand inhibition in cancer: the story of denosumab. Oncologist. 2011;16(2):136-45; PMID: 21285392; Contiene 55 referencias N2 - The diagnosis of bone metastases is an event with certain consequences for the patient. They often mean pain and can also mean pathological fractures, hypercalcemia, and spinal cord compression, all synonymous with a diminished quality of life and often also hospitalization. Since the advent of the intravenous bisphosphonates, things began to look a bit brighter for patients with bone metastases-bone destruction was kept at bay a little longer. The next generation of bone metastasis treatments is well on its way in clinical development, and among them, the most advanced drug is denosumab. Denosumab is a fully human monoclonal antibody that inhibits osteoclast maturation, activation, and function by binding to receptor activator of nuclear factor kappa B ligand, with the final result being a reduced rate of bone resorption. In this review, we give an overview of relevant preclinical and clinical data regarding the use of denosumab in patients with solid tumors in general and prostate cancer in particular. The Oncologist 2011; 16: 136-145 UR - http://pc-h12o-es.m-hdoct.a17.csinet.es/pdf/pc/7/pc7820a.pdf ER -