Estandarización de un modelo murino de malaria cerebral en fases clínicas para la evaluación de terapias antimaláricas y de rescate
Bautista, José M.
creator
Instituto de Investigación i+12
Díez, Amalia
creator
Instituto de Investigación i+12
Linares Gómez, María
creator
Instituto de Investigación i+12
Marín García, Patricia
creator
Instituto de Investigación i+12
Puyet, Antonio
creator
Instituto de Investigación i+12
Instituto de Investigación imas12
text
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Anales De La Real Academia Nacional De Farmacia
2013
eng
spa
79(2):274-92.
Cerebral malaria (CM) is included among the more devastating SNC infectious diseases due to its high mortality and severe sequelae in children. Currently, no specific pharmacological treatment for CM or rescue therapy for neurocognitive residual injury are available, and research on this topic has been hampered due to the lack of well-defined experimental models. In the present study we have characterized the CM murine infection phenotypically, evaluating clinical parameters, which allowed establishing a model encompassing four distinct disease stages. This protocol provides the experimental framework to study adjunctive neuroprotective therapies that may prevent and/or eliminate the neurological sequelae in individuals surviving CM.
Formato Vancouver:
Martínez G, Linares M, Marín-García P, Pérez-Benavente S, Puyet A, Bautista JM et al. Estandarización de un modelo murino de malaria cerebral en fases clínicas para la evaluación de terapias antimaláricas y de rescate. An Real Acad Nac Farm. 2013;79(2):274-92.
NO PMID
Contiene 40 referencias
http://pc-h12o-es.m-hdoct.a17.csinet.es/pdf/pc/5/pc529.pdf
http://pc-h12o-es.m-hdoct.a17.csinet.es/pdf/pc/5/pc529.pdf
130622
20210625062754.0