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The present and future of gene profiling in breast cancer. [artículo]

Por: Castañeda Altamirano, Carlos [Oncología Médica] | Ciruelos Gil, Eva María [Oncología Médica].
Colaborador(es): Servicio de Oncología Médica.
Editor: Cancer Metastasis Reviews, 2012Descripción: 31(1-2):41-6.Recursos en línea: Solicitar documento Resumen: Gene signatures can provide prognostic and predictive information to help in the treatment of early-stage breast cancer. Although many of these signatures have been described, only a few have been properly validated. MammaPrint and OncoType offer prognostic information and identify low-risk patients who do not benefit from adjuvant chemotherapy. With regard to prediction of response, molecular subtypes of breast cancer differ in their sensitivity to chemotherapy, although further studies are needed in this field. Cost, small sample size, and the need to use central laboratories are common limitations to the widespread use of these tools.
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Formato Vancouver:
Espinosa E, Gámez-Pozo A, Sánchez-Navarro I, Pinto A, Castañeda CA, Ciruelos E, et al. The present and future of gene profiling in breast cancer. Cancer Metastasis Rev. 2012 Jun;31(1-2):41-6.

PMID: 22124734

Contiene 47 referencias

Gene signatures can provide prognostic and predictive information to help in the treatment of early-stage breast cancer. Although many of these signatures have been described, only a few have been properly validated. MammaPrint and OncoType offer prognostic information and identify low-risk patients who do not benefit from adjuvant chemotherapy. With regard to prediction of response, molecular subtypes of breast cancer differ in their sensitivity to chemotherapy, although further studies are needed in this field. Cost, small sample size, and the need to use central laboratories are common limitations to the widespread use of these tools.

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