Benign Atypical Intravascular CD30(+) T-cell Proliferation: A Reactive Condition Mimicking Intravascular Lymphoma. [artículo]
Por: Rodríguez Peralto, José Luis [Anatomía Patológica]
| Riveiro Falkenbach, Erica [Instituto de Investigación i+12].
Colaborador(es): Servicio de Anatomía Patológica | Instituto de Investigación imas12.
Editor: American Journal of Dermatopathology, 2013Descripción: 35(2):143-50.Recursos en línea: Solicitar documento Resumen: CD30 is a transmembrane glycoprotein molecule usually expressed in activated B and T cells. Although it has been considered a reliable marker for CD30 lymphomas, reactive inflammatory disorders may contain a significant number of CD30(+) cells mimicking lymphoproliferative disorders clinically or histologically. Intravascular lymphoma is a rare variant of non-Hodgkin lymphoma that can involve the skin in 40% of the patients. The majority of cases show a B-cell phenotype, and only a minority of cases are of T-cell or NK-cell origin. Moreover, 2 aggressive cases of intravascular large T-cell lymphoma have been described with a CD30(+) phenotype. Herein, we report 2 patients with skin lesions showing an atypical intravascular CD30(+) T-cell proliferation. Both the patients did not present systemic disease and therefore exhibit a favorable outcome. To the best of our knowledge, this is the second report in the literature of a benign intravascular CD30(+) T-cell proliferation that represents an intriguing differential diagnosis for intravascular lymphoma.
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Formato Vancouver:
Riveiro-Falkenbach E, Fernández-Figueras MT, Rodríguez-Peralto JL. Benign atypical intravascular CD30(+) T-cell proliferation: a reactive condition mimicking intravascular lymphoma. Am J Dermatopathol. 2013 Apr;35(2):143-50.
PMID: 23542715
Contiene 14 referencias
CD30 is a transmembrane glycoprotein molecule usually expressed in activated B and T cells. Although it has been considered a reliable marker for CD30 lymphomas, reactive inflammatory disorders may contain a significant number of CD30(+) cells mimicking lymphoproliferative disorders clinically or histologically. Intravascular lymphoma is a rare variant of non-Hodgkin lymphoma that can involve the skin in 40% of the patients. The majority of cases show a B-cell phenotype, and only a minority of cases are of T-cell or NK-cell origin. Moreover, 2 aggressive cases of intravascular large T-cell lymphoma have been described with a CD30(+) phenotype. Herein, we report 2 patients with skin lesions showing an atypical intravascular CD30(+) T-cell proliferation. Both the patients did not present systemic disease and therefore exhibit a favorable outcome. To the best of our knowledge, this is the second report in the literature of a benign intravascular CD30(+) T-cell proliferation that represents an intriguing differential diagnosis for intravascular lymphoma.
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