Formato Vancouver:
Mazuecos A, Fernandez A, Andres A, Gomez E, Zarraga S, Burgos D, et al. HIV infection and renal transplantation. Nephrol Dial Transplant. 2011;26(4):1401-7.

PMID: 20858765

Contiene 27 referencias.

Background. Some aspects of kidney transplant outcome in human immunodeficiency virus (HIV)-infected patients are still controversial. Besides, published experience is scarce in Europe. Methods. A multicentre case-control study was designed to analyse the outcome of renal transplant in HIV+ patients in Spain. Twenty HIV+ patients were compared with a matched cohort of 40 HIV- recipients. Results. Post-transplant follow-up period was 39.98 +/- 36.51 months. Pre-transplant dialysis duration and the incidence of pre-transplant opportunistic infections were significantly higher for HIV+ patients. Following transplantation, HIV+ recipients presented lower incidence of immediate renal function and more acute rejection. Graft survival was lower although the difference was not significant (1 year: 85 vs 97.5%; 5 years: 74.4 vs 91%; log-rank P = 0.058). There was no difference in patient survival rates. Eight patients in each group presented hepatitis C (HCV) infection. Coinfected patients were compared with HIV+/HCV- and HIV-/HCV+ recipients. Coinfected patients presented more time on dialysis, greater duration of delayed graft function and lower graft survival (HIV+/HCV+ vs HIV+/HCV-: log-rank P = 0.009; HIV+/HCV+ vs HIV-/HCV+: log-rank P = 0.02). Conversely, when excluding HCV+ patients in both groups, graft survival in HIV+ and HIV- patients was similar. Conclusions. The outcome was good, particularly in non-coinfected patients. Coinfected patients constitute an especially high-risk group for kidney transplantation.