VIM-2-producing multidrug-resistant Pseudomonas aeruginosa ST175 clone, Spain. [artículo]
Por: Barrado Blanco, Laura [Microbiología y Parasitología]
| Chaves Sánchez, Fernando [Microbiología y Parasitología] | Orellana Miguel, María Ángeles [Microbiología y Parasitología] | Rodríguez Otero, Joaquín [Microbiología y Parasitología] | Sanz Sanz, Francisca [Microbiología y Parasitología] | Viedma Moreno, Esther [Instituto de Investigación i+12] | Villa García, Jennifer [Microbiología y Parasitología].
Colaborador(es): Servicio de Microbiología y Parasitología | Instituto de Investigación imas12.
Editor: Emerging Infectious Diseases, 2012Descripción: 18(8):1235-41.Recursos en línea: Solicitar documento Resumen: A total of 183 patients were colonized or infected with multidrug-resistant Pseudomonas aeruginosa isolates at a hospital in Spain during 2007-2010; prevalence increased over this period from 2.8% to 15.3%. To characterize these isolates, we performed molecular epidemiologic and drug resistance analysis. Genotyping showed that 104 (56.8%) isolates belonged to a single major clone (clone B), which was identified by multilocus sequence typing as sequence type (ST) 175. This clone was initially isolated from 5 patients in 2008, and then isolated from 23 patients in 2009 and 76 patients in 2010. PCR analysis of clone B isolates identified the bla(VIM-2) gene in all but 1 isolate, which harbored bla(IMP-22). ST175 isolates were susceptible to only amikacin (75%) and colistin (100%). Emergence of the ST175 clone represents a major health problem because it compromises therapy for treatment of P. aeruginosa nosocomial infections.
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Formato Vancouver:
Viedma E, Juan C, Villa J, Barrado L, Orellana MA, Sanz F, et al. VIM-2-producing multidrug-resistant Pseudomonas aeruginosa ST175 clone, Spain. Emerg Infect Dis. 2012 Aug;18(8):1235-41.
PMID: 22840969
Contiene 37 referencias
A total of 183 patients were colonized or infected with multidrug-resistant Pseudomonas aeruginosa isolates at a hospital in Spain during 2007-2010; prevalence increased over this period from 2.8% to 15.3%. To characterize these isolates, we performed molecular epidemiologic and drug resistance analysis. Genotyping showed that 104 (56.8%) isolates belonged to a single major clone (clone B), which was identified by multilocus sequence typing as sequence type (ST) 175. This clone was initially isolated from 5 patients in 2008, and then isolated from 23 patients in 2009 and 76 patients in 2010. PCR analysis of clone B isolates identified the bla(VIM-2) gene in all but 1 isolate, which harbored bla(IMP-22). ST175 isolates were susceptible to only amikacin (75%) and colistin (100%). Emergence of the ST175 clone represents a major health problem because it compromises therapy for treatment of P. aeruginosa nosocomial infections.
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