Harmful Effects of Viral Replication in Seropositive Hepatitis C Virus Renal Transplant Recipients. [artículo]
Por: Morales Cerdán, José María [Nefrología]
.
Colaborador(es): Servicio de Nefrología.
Tipo de material: 
LibroEditor: Transplantation, 2012Descripción: 94(11):1131-7.Recursos en línea: Solicitar documento Resumen: Background. Seropositivity for hepatitis C virus (HCV) predicts lower patient and graft survival after renal transplantation
(RT). However, the influence of viral replication at transplantation on long-term outcome remains to be determined.
Methods. This was a retrospective study conducted in four Spanish hospitals, from 1997 to 2006. Data of all patients
with RT, who displayed HCV+ (enzyme-linked immunosorbent assay), and with negative viremia at RT (NEG
group) were collected (n=41). For each NEG patient enrolled, data of two patients with RT nearest in time, HCV+,
and positive viremia (POS group) were also collected (n=78).
Results. The POS group showed a higher incidence of long-term liver disease (56.4% vs. 24.4%, P=0.0009)
and episodes of transaminase elevation (38.5% vs. 7.3%, P=0.0003) and worse renal function (serum creatinine [sCr],
3.0 [2.7] vs. 1.9 [1.6] mg/dl, P=0.032; glomerular filtration rate, 43.7 [22.4] vs. 56.9 [27.9] ml/min, P=0.075).
Noteworthy, 24.4% of NEG patients reactivated after RT, showing a worse patient survival (P=0.039). Active viral
replication at RT and dialysis requirement in the first week remained as independent predictors of lower graft survival
(death censored): hazards ratio, 3.11 (95% confidence interval, 1.34Y7.19; P=0.009) and hazards ratio 3.13 (95%
confidence interval, 1.53Y6.37; P=0.002).
Conclusions. This study shows that active viral replication at transplantation is an independent risk factor for graft
failure in patients with positive serology for HCV.
| Tipo de ítem | Ubicación actual | Signatura | Estado | Fecha de vencimiento |
|---|---|---|---|---|
Artículo
|
PC7858 (Navegar estantería) | Disponible |
Navegando Hospital Universitario 12 de Octubre Estantes Cerrar el navegador de estanterías
Formato Vancouver:
Gentil Govantes MA, Esforzado N, Cruzado JM, González-Roncero FM, Balaña M, Saval N, et al. Harmful effects of viral replication in seropositive hepatitis C virus renal transplant recipients. Transplantation. 2012 Dec 15;94(11):1131-7.
PMID: 23104249
Contiene 35 referencias
Background. Seropositivity for hepatitis C virus (HCV) predicts lower patient and graft survival after renal transplantation
(RT). However, the influence of viral replication at transplantation on long-term outcome remains to be determined.
Methods. This was a retrospective study conducted in four Spanish hospitals, from 1997 to 2006. Data of all patients
with RT, who displayed HCV+ (enzyme-linked immunosorbent assay), and with negative viremia at RT (NEG
group) were collected (n=41). For each NEG patient enrolled, data of two patients with RT nearest in time, HCV+,
and positive viremia (POS group) were also collected (n=78).
Results. The POS group showed a higher incidence of long-term liver disease (56.4% vs. 24.4%, P=0.0009)
and episodes of transaminase elevation (38.5% vs. 7.3%, P=0.0003) and worse renal function (serum creatinine [sCr],
3.0 [2.7] vs. 1.9 [1.6] mg/dl, P=0.032; glomerular filtration rate, 43.7 [22.4] vs. 56.9 [27.9] ml/min, P=0.075).
Noteworthy, 24.4% of NEG patients reactivated after RT, showing a worse patient survival (P=0.039). Active viral
replication at RT and dialysis requirement in the first week remained as independent predictors of lower graft survival
(death censored): hazards ratio, 3.11 (95% confidence interval, 1.34Y7.19; P=0.009) and hazards ratio 3.13 (95%
confidence interval, 1.53Y6.37; P=0.002).
Conclusions. This study shows that active viral replication at transplantation is an independent risk factor for graft
failure in patients with positive serology for HCV.
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