Formato Vancouver:
Palomo T, Beninger RJ, Jiménez Arriero MA, Huertas E. El espectro bipolar. Madrid: Editorial CYM; 2002.

Insulin-like growth factor I (IGF-I), a neuroprotective factor with a wide spectrum of actions in the adult brain is involved in the pathogenesis of Alzheimer's disease (AD). Circulating levels of IGF-I change in AD patients and are implicated in the clearance of brain amyloid beta (Lambda beta) complexes. To investigate this hypothesis, we screened the IGF-I gene for various well known single nucleotide polymorphisms (SNPs) covering % of the gene variability in a population of 2352 individuals. Genetic analysis indicated different distribution of genotypes of 1 single nucleotide polymorphism., and 1 extended haplotype in the AD population compared with healthy control subjects. In particular, the frequency of rs972936 GC, genotype was significantly greater in AD patients than in control subjects (63% vs. 55%). The rs972936 GG genotype was associated with an increased risk for disease, independently of apolipoprotein E genotype, and with enhanced circulating levels of IGF-I. These findings suggest that polymorphisms within the IGF-I gene could infer greater risk for AD through their effect on ICE-I levels, and confirm the physiological role IGF-I in the pathogenesis of AD. (C) 2011 IBRO All rights reserved.