Single-nucleotide polymorphisms at the 9p21.3 genomic region not associated with the risk of cardiovascular disease in patients with rheumatoid arthritis. [artículo]
Por: Carreira Delgado, Patricia Esmeralda [Reumatología]
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Colaborador(es): Servicio de Reumatología.
Editor: Tissue Antigens, 2013Descripción: 82(6):405-9.Recursos en línea: Solicitar documento Resumen: Rheumatoid arthritis (RA) is a chronic polygenic inflammatory disease associated with accelerated atherosclerosis and high risk of cardiovascular disease (CVD). In this study, we evaluated the potential association of 9p21.3 single-nucleotide polymorphisms (SNPs)-previously linked to coronary artery disease-and CVD risk in 2001 Spanish RA patients genotyped for 9p21.3 SNPs using TaqMan assays. Carotid intima media thickness (cIMT) and presence of carotid plaques were also analyzed. Cox regression model did not disclose significant differences between patients who experienced CVD and those who did not. Neither association was found between cIMT or carotid plaques and SNPs allele distribution. In conclusion, results do not support a role of rs10116277 or rs1537375 SNPs in CVD risk in Spanish RA patients.
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Formato Vancouver:
García-Bermúdez M, López-Mejías R, Genre F, Castañeda S, González-Juanatey C, Llorca J et al. Single-nucleotide polymorphisms at the 9p21.3 genomic region not associated
with the risk of cardiovascular disease in patients with rheumatoid arthritis. Tissue Antigens. 2013 Dec;82(6):405-9.
PMID: 24498997
Contiene 35 referencias
Rheumatoid arthritis (RA) is a chronic polygenic inflammatory disease associated with accelerated atherosclerosis and high risk of cardiovascular disease (CVD). In this study, we evaluated the potential association of 9p21.3 single-nucleotide polymorphisms (SNPs)-previously linked to coronary artery disease-and CVD risk in 2001 Spanish RA patients genotyped for 9p21.3 SNPs using TaqMan assays. Carotid intima media thickness (cIMT) and presence of carotid plaques were also analyzed. Cox regression model did not disclose significant differences between patients who experienced CVD and those who did not. Neither association was found between cIMT or carotid plaques and SNPs allele distribution. In conclusion, results do not support a role of rs10116277 or rs1537375 SNPs in CVD risk in Spanish RA patients.
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