The influence of immunosuppression switching in liver function in adult hepatic transplantation [artículo]
Por: Abradelo de Usera, Manuel [Cirugía General y Aparato Digestivo]
| Gómez Sanz, Ramón [Cirugía General y del Aparato Digestivo] | Jiménez Romero, Carlos [Cirugía General y del Aparato Digestivo] | Loinaz Segurola, Carmelo [Cirugía General y del Aparato Digestivo] | Meneu Díaz, Juan Carlos [Cirugía General y del Aparato Digestivo] | Moreno Elola-Olaso, Almudena [Cirugía General y del Aparato Digestivo] | Moreno González, Enrique [Cirugía General y del Aparato Digestivo].
Colaborador(es): Servicio de Cirugía General y del Aparato Digestivo.
Editor: Hepatogastroenterology, 2011Descripción: 58(106):532-535. Tipo de medio: JOUR Recursos en línea: Solicitar documento Resumen: We evaluate the 5-year results of a single-centre prospective randomized trial that compared cyclosporine microemulsion (CyA-me) in triple therapy (plus steroids and azathioprine) and Tacrolimus (Tac) in double therapy (plus steroids) for primary immunosuppression. One hundred adult patients undergoing liver transplantation were randomized to receive Tac (n=51) or CyA-me (n=49). Ten patients in group A, and thirty-one patients in group B had their main immunosuppressive agent switched. The switch was much more frequent from CyA-me to Tac (n=31; 62.3%), mainly because of lack of efficacy (n=12; 38.7%). Six of 10 patients were shifted from Tac to CyA-me for side effects. The clinical course of the majority of patients converted from CyA-me to Tac improved clearly after conversion. Donor age and acute rejection (number, severity and rejection free days) had a significative association with lack of efficacy in group B. In these series, the conversion to Tac from CyA-me could be accomplished safely, with an excellent long-term outcome.
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Formato Vancouver:
Marín Gómez LM, Loinaz Segurota C, Moreno González E, Moreno Elola-Olaso A, González-Pinto Arrillaga I, Meneu Díaz JC, et al. The influence of immunosuppression switching in liver function in adult hepatic transplantation. Hepatogastroenterology. 2011;58(106):532-5.
PMID: 21661426
Contiene 10 referencias
We evaluate the 5-year results of a single-centre prospective randomized trial that compared cyclosporine microemulsion (CyA-me) in triple therapy (plus steroids and azathioprine) and Tacrolimus (Tac) in double therapy (plus steroids) for primary immunosuppression. One hundred adult patients undergoing liver transplantation were randomized to receive Tac (n=51) or CyA-me (n=49). Ten patients in group A, and thirty-one patients in group B had their main immunosuppressive agent switched. The switch was much more frequent from CyA-me to Tac (n=31; 62.3%), mainly because of lack of efficacy (n=12; 38.7%). Six of 10 patients were shifted from Tac to CyA-me for side effects. The clinical course of the majority of patients converted from CyA-me to Tac improved clearly after conversion. Donor age and acute rejection (number, severity and rejection free days) had a significative association with lack of efficacy in group B. In these series, the conversion to Tac from CyA-me could be accomplished safely, with an excellent long-term outcome.
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