The CD4/CD8 Ratio as a Marker T-cell Activation, Senescence and Activation/Exhaustion in Treated HIV-Infected Children and Young Adults [artículo]
Por: González Tomé, María Isabel [Pediatría]
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Colaborador(es): Servicio de Pediatría-Neonatología.
Editor: AIDS (London, England), 2013Descripción: 27(9):1513-6.Recursos en línea: Solicitar documento Resumen: We explored the associations of the CD4/CD8 ratio with markers of immunoactivation, immunosenescence and T-cell subsets, in 37 vertically HIV-infected children and adolescents. CD4/CD8 ratio inversion was associated with higher frequencies of activated, senescent and activated/exhausted CD4and CD8 T-cells, and a skewed T-cell phenotype from naïve toward effector memory which persisted after the multivariate analysis. Thus, the CD4/CD8 ratio may identify subjects with higher immunoactivation despite ART.
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Artículo
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Formato Vancouver:
Sainz T, Serrano-Villar S, Díaz L, González Tomé MI, Gurbindo MD, de José MI et al. The CD4/CD8 ratio
as a marker T-cell activation, senescence and activation/exhaustion in treated HIV-infected children and young adults. AIDS. 2013 Jun 1;27(9):1513-6.
PMID: 23435292
Contiene 21 referencias
We explored the associations of the CD4/CD8 ratio with markers of immunoactivation, immunosenescence and T-cell subsets, in 37 vertically HIV-infected children and adolescents. CD4/CD8 ratio inversion was associated with higher frequencies of activated, senescent and activated/exhausted CD4and CD8 T-cells, and a skewed T-cell phenotype from naïve toward effector memory which persisted after the multivariate analysis. Thus, the CD4/CD8 ratio may identify subjects with higher immunoactivation despite ART.
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