Codeletion of 1p and 19q determines distinct gene methylation and expression profiles in IDH-mutated oligodendroglial tumor.s [artículo]
Por: Ruano Domínguez, Yolanda [Instituto de Investigación i+12]
| Hernández Laín, Aurelio [ Anatomía Patológica].
Colaborador(es): Servicio de Anatomía Patológica | Instituto de Investigación imas12.
Editor: Acta neuropathologica, 2013Descripción: 126(2):277-89.Recursos en línea: Solicitar documento Resumen: Oligodendroglial tumors (OTs) are primary brain tumors that show variable clinical and biological behavior. The 1p/19q codeletion is frequent in these tumors, indicating a better prognosis and/or treatment response. Recently, the prognostically favorable CpG island methylator phenotype (CIMP) in gliomas (G-CIMP+) was associated with mutations in the isocitrate dehydrogenase 1 and isocitrate dehydrogenase 2 (IDH) genes, as opposed to G-CIMP- tumors, highlighting the relevance of epigenetic mechanisms.
| Tipo de ítem | Ubicación actual | Signatura | Estado | Fecha de vencimiento |
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Artículo
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PC5235 (Navegar estantería) | Disponible |
Formato Vancouver:
Mur P, Mollejo M, Ruano Y, de Lope ÁR, Fiaño C, García JF et al. Codeletion of 1p and 19q determines distinct gene methylation and expression profiles in IDH-mutated oligodendroglial tumors. Acta Neuropathol. 2013 Aug;126(2):277-89.
PMID: 23689617
Contiene 59 referencias
Oligodendroglial tumors (OTs) are primary brain tumors that show variable clinical and biological behavior. The 1p/19q codeletion is frequent in these tumors, indicating a better prognosis and/or treatment response. Recently, the prognostically favorable CpG island methylator phenotype (CIMP) in gliomas (G-CIMP+) was associated with mutations in the isocitrate dehydrogenase 1 and isocitrate dehydrogenase 2 (IDH) genes, as opposed to G-CIMP- tumors, highlighting the relevance of epigenetic mechanisms.
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