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Sarcoidosis simulando una histiocitosis no Langerhans, tratada con antagonistas del factor de necrosis tumoral alpha [artículo]

Por: Burgués Calderón, Mar [Dermatología Médico-Quirúrgica] | Castellanos González, María [Dermatología Médico-Quirúrgica y Venereología] | Rodríguez Peralto, José Luis [Anatomía Patológica] | Hebe Petiti-Martin, Gisele [Dermatología Médico-Quirúrgica y Venereología] | Sanz Bueno, Jimena [Dermatología Médico-Quirúrgica y Venereología] | Vanaclocha Sebastián, Francisco [Dermatología Médico Quirúrgica y Venereología] | Villar Buill, María [Dermatología Médico-Quirúrgica y Venereología].
Colaborador(es): Servicio de Dermatología Médico-Quirúrgica y Venereología | Servicio de Anatomía Patológica.
Editor: Anales de Pediatría, 2012Descripción: 77(4):267-271.Recursos en línea: Solicitar documento Resumen: Sarcoidosis is a chronic multisystemic granulomatous disease of unknown origin. Generalised eruptive histiocytosis is a rare, benign, self-healing, non-Langerhans' cell histiocytosis (non-LCH). We report the case of an 8-year-old girl with sarcoidosis who was misdiagnosed as non-LCH. She was treated with oral corticosteroids, methotrexate and adalimumab, but there was insufficient control of ocular disease. The introduction of infliximab achieved a control of the uveitis and enabled the corticosteroid dose to be tapered. In some cases of sarcoidosis the lack of well-organised granuloma formation at the beginning of the disease, and the presence of prominent giant cells may suggest alternative diagnoses, such as non-LCH. Although the experience of tumour necrosis factor-alpha antagonists use in children with sarcoidosis is limited, these drugs may be helpful for those patients experiencing a severe and refractory disease.
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Formato Vancouver:
Petiti Martin G, Castellanos González M, Sanz Bueno J, Burgués Calderón M, Villar Buil M, Vanaclocha F, et al. Sarcoidosis simulando una histiocitosis no Langerhans, tratada con antagonistas del factor de necrosis tumoral alpha. An Pediatr (Barc). 2012;77(4):267-71.

PMID: 22608978

Contiene 18 referencias

Sarcoidosis is a chronic multisystemic granulomatous disease of unknown origin. Generalised eruptive histiocytosis is a rare, benign, self-healing, non-Langerhans' cell histiocytosis (non-LCH). We report the case of an 8-year-old girl with sarcoidosis who was misdiagnosed as non-LCH. She was treated with oral corticosteroids, methotrexate and adalimumab, but there was insufficient control of ocular disease. The introduction of infliximab achieved a control of the uveitis and enabled the corticosteroid dose to be tapered. In some cases of sarcoidosis the lack of well-organised granuloma formation at the beginning of the disease, and the presence of prominent giant cells may suggest alternative diagnoses, such as non-LCH. Although the experience of tumour necrosis factor-alpha antagonists use in children with sarcoidosis is limited, these drugs may be helpful for those patients experiencing a severe and refractory disease.

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