Hypocomplementemia in Kidney Transplant Recipients: Impact on the Risk of Infectious Complications. [artículo]
Por: Aguado García, José María [Enfermedades Infecciosas]
| Andrés Belmonte, Amado [Nefrología] | García Reyne, Ana [Medicina Interna] | López Medrano, Francisco [Enfermedades Infecciosas] | Lora Pablos, David [Instituto Investigación I+12] | Lumbreras Bermejo, Carlos [Medicina Interna] | Morales Cerdán, José María [Nefrología] | Paz Artal, Estela [Inmunología] | Polanco Fernández, Natalia [Nefrología] | San Juan Garrido, Rafael [Medicina Interna] | Varela Peña, P [Inmunología] | Fernández Ruiz, Mario [Medicina Interna].
Colaborador(es): Servicio de Medicina Interna | Servicio de Nefrología | Servicio de Inmunología | Instituto de Investigación imas12.
Editor: American Journal of Transplantation, 2013Descripción: 13(3):685-94.Recursos en línea: Solicitar documento Resumen: The usefulness of monitoring of complement levels in predicting the occurrence of infection in kidney transplant (KT) recipients remains largely unknown. We prospectively assessed serum complement levels (C3 and C4) at baseline and at months 1 and 6 in 270 patients undergoing KT. Adjusted hazard ratios (aHRs) for infection in each posttransplant period were estimated by Cox regression. The prevalence of C3 hypocomplementemia progressively decreased from 21.5% at baseline to 11.6% at month 6 (p = 0.017), whereas the prevalence of C4 hypocomplementemia rose from 3.7% at baseline to 9.2% at month 1 (p = 0.004). Patients with C3 hypocomplementemia at month 1 had higher incidences of overall (p = 0.002), bacterial (p = 0.004) and fungal infection (p = 0.019) in the intermediate period (months 16). On multivariate analysis C3 hypocomplementemia at month 1 emerged as a risk factor for overall (aHR 1.911; p = 0.009) and bacterial infection (aHR 2.130; p = 0.014) during the intermediate period, whereas C3 hypocomplementemia at month 6 predicted the occurrence of bacterial infection (aHR 3.347; p = 0.039) in the late period (>6 month). A simple monitoring strategy of serum C3 levels predicts the risk of posttransplant infectious complications in KT recipients.
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Artículo
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PC3846 (Navegar estantería) | Disponible |
Formato Vancouver:
Fernández-Ruiz M, López-Medrano F, Varela-Peña P, Morales JM, García-Reyne A, San Juan R et al. Hypocomplementemia in kidney transplant recipients: impact on the risk of infectious complications. Am J Transplant. 2013 Mar;13(3):685-94.
PMID: 23311502
Contiene 37 referencias
The usefulness of monitoring of complement levels in predicting the occurrence of infection in kidney transplant (KT) recipients remains largely unknown. We prospectively assessed serum complement levels (C3 and C4) at baseline and at months 1 and 6 in 270 patients undergoing KT. Adjusted hazard ratios (aHRs) for infection in each posttransplant period were estimated by Cox regression. The prevalence of C3 hypocomplementemia progressively decreased from 21.5% at baseline to 11.6% at month 6 (p = 0.017), whereas the prevalence of C4 hypocomplementemia rose from 3.7% at baseline to 9.2% at month 1 (p = 0.004). Patients with C3 hypocomplementemia at month 1 had higher incidences of overall (p = 0.002), bacterial (p = 0.004) and fungal infection (p = 0.019) in the intermediate period (months 16). On multivariate analysis C3 hypocomplementemia at month 1 emerged as a risk factor for overall (aHR 1.911; p = 0.009) and bacterial infection (aHR 2.130; p = 0.014) during the intermediate period, whereas C3 hypocomplementemia at month 6 predicted the occurrence of bacterial infection (aHR 3.347; p = 0.039) in the late period (>6 month). A simple monitoring strategy of serum C3 levels predicts the risk of posttransplant infectious complications in KT recipients.
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