Formato Vancouver:
Meca-Lallana JE, Balseiro JJ, Lacruz F, Guijarro C, Sánchez O, Cano A, et al. Spasticity improvement in patients with relapsing-remitting multiple sclerosis switching from interferon-β to glatiramer acetate: the Escala Study. J Neurol Sci. 2012 Apr 15;315(1-2):123-8.

PMID: 22133480

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Background: A recent pilot study suggested spasticity improvement during glatiramer acetate (GA) treatment
in multiple sclerosis (MS) patients who previously received interferon-β (IFN-β).
Objective: To evaluate changes in spasticity in MS patients switching from IFN-β to GA.
Methods: Observational, multicentre study in patients with relapsing–remitting MS (RRMS) and spasticity
switching from IFN-β to GA. The primary endpoint comprised changes on Penn Spasm Frequency Scale
(PSFS), Modified Ashworth Scale (MAS), Adductor Tone Rating Scale (ATRS), and Global Pain Score (GPS)
at months 3 and 6 after starting GA.
Results: Sixty-eight evaluable patientswere included (mean age,41.7±9.5 years; female,70.6%; mean time from
MS diagnosis to starting GA,7.6±5.7 years). Previous treatments were subcutaneous IFN-β1a in 42.6% patients,
intramuscular IFN-β1a in 41.2% and IFN-β1b in 32.4%,whosemean durations were 3.5±3.3, 2.7±2.5 and 4.4±
3.6 years, respectively. Statistically significant reductions in mean scores on all spasticity measurements
were observed from baseline to month 3 (PSFS, 1.7±0.9 vs 1.4±0.6, pb0.01; MAS, 0.7±0.5 vs 0.6±0.5,
pb0.01; highest MAS score, 1.9±0.8 vs 1.7±0.8, pb0.01; ATRS, 1.6±0.6 vs 1.4±0.6, pb0.01; GPS, 29.4± 22.1 vs 24.7±19.4, pb0.01) and from baseline to month 6 (PSFS, 1.7±0.9 vs 1.3±0.6, pb0.01; MAS, 0.7±0.5 vs 0.5±0.5, pb0.01; highest MAS score, 1.9±0.8 vs 1.5±0.9, pb0.01; ATRS, 1.6±0.6 vs 1.3±0.6, pb0.01; GPS, 29.4±22.1 vs 19.1±14.8, pb0.01).
Conclusion: Spasticity improvement in terms of spasm frequency,muscle tone and pain can be noted after three
months and prolonged for six months of GA treatment.