Liver transplantation from anti-hepatitis C virus-positive donors: our experience [artículo]
Por: Abradelo de Usera, Manuel [Cirugía General y Aparato Digestivo]
| Alegre Torrado, Cristina [Cirugía General y Aparato Digestivo] | Álvaro Cifuentes, Edurne [Cirugía General y del Aparato Digestivo] | Calvo Pulido, Jorge [Cirugía General y del Aparato Digestivo] | Cambra Molero, Félix [Cirugía General y del Aparato Digestivo] | Colina Ruiz-Delgado, Francisco [Anatomía Patológica] | Fuertes Ortiz de Urbina, Antonio [Microbiología y Parasitología] | García Ureña, Miguel A [Cirugía General y del Aparato Digestivo] | García-Sesma Pérez-Fuentes, Álvaro [Cirugía General y del Aparato Digestivo] | Jiménez Romero, Carlos [Cirugía General y del Aparato Digestivo] | Manrique Municio, Alejandro [Cirugía General y del Aparato Digestivo] | Moreno González, Enrique [Cirugía General y del Aparato Digestivo] | Sanabria Mateos, Rebeca [Cirugía General y del Aparato Digestivo].
Colaborador(es): Servicio de Cirugía General y del Aparato Digestivo | Servicio de Anatomía Patológica | Servicio de Microbiología y Parasitología.
Editor: Transplantation Proceedings, 2012Descripción: 44(6):1475-1478.Recursos en línea: Solicitar documento Resumen: Background. Hepatitis C (HCV) is among the most common causes of end-stage liver disease worldwide. The donor shortage leads us to consider alternative organ sources such as HCV-positive donors. The outcomes of these transplants must be evaluated thoroughly since there is universal recurrence of disease among HCV-positive liver transplant recipients. Methods. From January 2005 to April 2011, we performed 143 liver transplants (OLT) to treat end-stage liver disease secondary to HCV infection. Thirteen patients (9,1%) received livers from HCV-positive donors. A control group consisted of 130 HCV-positive patients who underwent OLT during the same period with organs from HCV-negative. donors. Donor HCV status was assessed by 2 tests: HCV antibodies and viral load. Not only recipient and graft survivals were analyzed, but also frequency, timing and severity of hepatitis recurrence. Results. Among 143 transplants performed in HCV-positive recipients during a 6-year period from January 1, 2005, to April 30, 2011,. 9.1% of patients received an organ from an anti-HCV-positive donor, 72.7% of whom showed a negative viral load. The vast majority (80%) of our patients suffered hepatitis during their follow-up, 22.4% of which were severe cases. Conclusions. No significant difference in patient or graft survival was observed between the 2 groups. A high percentage of grafts with initial positive serology for HCV showed no viral replication. Grafts from HCV-positive donors can be considered to be a safe, effective source for liver donation.
| Tipo de ítem | Ubicación actual | Signatura | Estado | Fecha de vencimiento |
|---|---|---|---|---|
Artículo
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PC2264 (Navegar estantería) | Disponible |
Navegando Hospital Universitario 12 de Octubre Estantes Cerrar el navegador de estanterías
Formato Vancouver:
Álvaro E, Abradelo M, Fuertes A, Manrique A, Colina F, Alegre C, et al. Liver transplantation from anti-hepatitis C virus-positive donors: our experience. Transplant Proc. 2012;44(6):1475-8.
PMID: 22841188
Contiene 12 referencias
Background. Hepatitis C (HCV) is among the most common causes of end-stage liver disease worldwide. The donor shortage leads us to consider alternative organ sources such as HCV-positive donors. The outcomes of these transplants must be evaluated thoroughly since there is universal recurrence of disease among HCV-positive liver transplant recipients. Methods. From January 2005 to April 2011, we performed 143 liver transplants (OLT) to treat end-stage liver disease secondary to HCV infection. Thirteen patients (9,1%) received livers from HCV-positive donors. A control group consisted of 130 HCV-positive patients who underwent OLT during the same period with organs from HCV-negative. donors. Donor HCV status was assessed by 2 tests: HCV antibodies and viral load. Not only recipient and graft survivals were analyzed, but also frequency, timing and severity of hepatitis recurrence. Results. Among 143 transplants performed in HCV-positive recipients during a 6-year period from January 1, 2005, to April 30, 2011,. 9.1% of patients received an organ from an anti-HCV-positive donor, 72.7% of whom showed a negative viral load. The vast majority (80%) of our patients suffered hepatitis during their follow-up, 22.4% of which were severe cases. Conclusions. No significant difference in patient or graft survival was observed between the 2 groups. A high percentage of grafts with initial positive serology for HCV showed no viral replication. Grafts from HCV-positive donors can be considered to be a safe, effective source for liver donation.
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