Higher glutamate to glutamine ratios in occipital regions in women with migraine during the interictal state. [artículo]
Por: González de la Aleja Tejera, Jesús [Neurología]
| Hernández Gallego, Jesús [Neurología] | Martínez Salio, Antonio [Neurología] | Ramos González, Ana [Radiodiagnóstico] | Molina Arjona, José Antonio [Neurología].
Colaborador(es): Servicio de Neurología-Neurofisiología | Servicio de Radiodiagnóstico.
Editor: Headache, 2013Descripción: 53(2):365-75.Recursos en línea: Solicitar documento Resumen: BACKGROUND: Glutamate (Glu) and glutamine (Gln) are strongly compartmentalized (in neurons for Glu and in astrocytes for Gln). The visual cortex is the brain region with a higher neuron/astrocyte ratio (the highest neuronal density and the relatively lowest density of astrocytes). Elevations in extracellular Glu or potassium above certain thresholds are likely candidates to be the final common steps in the multiple distinct processes that can lead to cortical spreading depression. Astrocytes play a key role in this phenomenon, by acting as a sink for extracellular Glu and potassium, as well as generally acting as a buffer for the ionic and neurochemical changes that initiate and propagate cortical spreading depression.
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Formato Vancouver:
González de la Aleja J, Ramos A, Mato-Abad V, Martínez-Salio A, Hernández-Tamames JA, Molina JA et al. Higher glutamate to glutamine ratios in occipital regions in women with migraine during the interictal state. Headache. 2013 Feb;53(2):365-75.
PMID: 23278319
Contiene 45 referencias
BACKGROUND: Glutamate (Glu) and glutamine (Gln) are strongly compartmentalized (in neurons for Glu and in astrocytes for Gln). The visual cortex is the brain region with a higher neuron/astrocyte ratio (the highest neuronal density and the relatively lowest density of astrocytes). Elevations in extracellular Glu or potassium above certain thresholds are likely candidates to be the final common steps in the multiple distinct processes that can lead to cortical spreading depression. Astrocytes play a key role in this phenomenon, by acting as a sink for extracellular Glu and potassium, as well as generally acting as a buffer for the ionic and neurochemical changes that initiate and propagate cortical spreading depression.
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