Tailoring the biological response of mesoporous bioactive materials. [artículo]
Por: Gómez Cerezo, N [Instituto de Investigación imas12]
| Izquierdo Barba, Isabel [Instituto de Investigación imas12] | Arcos, Daniel [Instituto de Investigación imas12] | Vallet Regí, María [Instituto de Investigación imas12].
Colaborador(es): Instituto de Investigación imas12.
Tipo de material: 
ArtículoEditor: Journal of materials chemistry. B, 2015Descripción: 3(18):3810-3819.Recursos en línea: Solicitar documento Resumen: Mesoporous bioactive glasses (MBGs) in the SiO2-CaO-P2O5 system have been prepared using different non-ionic structure directing agents (SDA): Brij58, F68, P123 and F127. For the first time, the bioactive response of MBGs can be tailored with the kind of SDA incorporated. This is because, in addition to the textural properties, we can use the SDA to tailor the local atomic environment within the MBG struts. These features lead to differences in the in vitro bioactive behaviour of MBGs. Among the different SDAs used in this work, the triblock copolymer F68 leads to MBGs that exhibit the fastest bioactivity and the fastest differentiation induction from a pre-osteoblast to an osteoblast phenotype. These results are explained in terms of a highly ordered mesoporous structure, more free calcium cations acting as silica network modifiers and small mesopores that avoid the formation of CaP nuclei within pores, which could obstruct the ionic exchange with the surrounding fluids.
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Artículo
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Formato Vancouver:
Gómez Cerezo N , Izquierdo Barba I , Arcos D , Vallet Regí M . Tailoring the biological response of mesoporous bioactive materials. J Mater Chem B. 2015 May 14;3(18):3810-3819.
PMID: 32262855
Contiene 54 referencias
Mesoporous bioactive glasses (MBGs) in the SiO2-CaO-P2O5 system have been prepared using different non-ionic structure directing agents (SDA): Brij58, F68, P123 and F127. For the first time, the bioactive response of MBGs can be tailored with the kind of SDA incorporated. This is because, in addition to the textural properties, we can use the SDA to tailor the local atomic environment within the MBG struts. These features lead to differences in the in vitro bioactive behaviour of MBGs. Among the different SDAs used in this work, the triblock copolymer F68 leads to MBGs that exhibit the fastest bioactivity and the fastest differentiation induction from a pre-osteoblast to an osteoblast phenotype. These results are explained in terms of a highly ordered mesoporous structure, more free calcium cations acting as silica network modifiers and small mesopores that avoid the formation of CaP nuclei within pores, which could obstruct the ionic exchange with the surrounding fluids.
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