Rationale and Design of a Randomized Controlled Trial Evaluating Whole Muscle Exercise Training Effects in Outpatients with Pulmonary Arterial Hypertension (WHOLEi+12). [artículo]
Por: Sanchis Gomar, Fabián [Instituto de Investigación imas12]
| González Saiz, Laura [Instituto de Investigación imas12] | Sanz Ayán, María Paz [Medicina Física y Rehabilitación] | Fiuza Luces, Carmen [Instituto de Investigación i+12] | Quezada Loaiza, Carlos Andrés [Neumología] | Flox Camacho, Ángela [Cardiología].
Colaborador(es): Instituto de Investigación imas12 | Servicio de Medicina Física y Rehabilitación | Servicio de Cardiología | Servicio de Neumología.
Tipo de material: 
ArtículoEditor: Cardiovascular drugs and therapy, 2015Descripción: 29(6):543-550.Recursos en línea: Solicitar documento Resumen: Background and aims: Physical exercise is an important component in the management of pulmonary artery hypertension (PAH). The aim of this randomized controlled trial (RCT) is to determine the effects of an 8-week intervention combining muscle resistance, aerobic and inspiratory pressure load exercises in PAH outpatients.
Methods: The RCT will be conducted from September 2015 to September 2016 following the recommendations of the Consolidated Standards of Reported Trials (CONSORT), with a total sample size of n ≥ 48 (≥24 participants/group). We will determine the effects of the intervention on: (i) skeletal-muscle power and mass (primary end points); and (ii) NT-proBNP, cardiopulmonary exercise testing variables (VO2peak, ventilatory equivalent for CO2 at the anaerobic threshold (VE/VCO2 at the AT), end-tidal pressure of CO2 at the anaerobic threshold (PETCO2 at the AT), 6-min walking distance (6MWD), maximal inspiratory pressure (PImax), health-related quality of life (HRQoL), objectively-assessed spontaneous levels of physical activity, and safety (secondary end points).
Conclusions and perspectives: This trial will provide insight into biological mechanisms of the disease and indicate the potential benefits of exercise in PAH outpatients, particularly on muscle power.
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Formato Vancouver:
Sanchís Gomar F, González Saiz L, Sanz Ayan P, Fiuza Luces C, Quezada Loaiza CA, Flox Camacho A et al. Rationale and Design of a Randomized Controlled Trial Evaluating Whole Muscle Exercise Training Effects in Outpatients with Pulmonary Arterial Hypertension (WHOLEi+12). Cardiovasc Drugs Ther. 2015 Dec;29(6):543-550.
PMID: 26521182
Contiene 313 referencias
Background and aims: Physical exercise is an important component in the management of pulmonary artery hypertension (PAH). The aim of this randomized controlled trial (RCT) is to determine the effects of an 8-week intervention combining muscle resistance, aerobic and inspiratory pressure load exercises in PAH outpatients.
Methods: The RCT will be conducted from September 2015 to September 2016 following the recommendations of the Consolidated Standards of Reported Trials (CONSORT), with a total sample size of n ≥ 48 (≥24 participants/group). We will determine the effects of the intervention on: (i) skeletal-muscle power and mass (primary end points); and (ii) NT-proBNP, cardiopulmonary exercise testing variables (VO2peak, ventilatory equivalent for CO2 at the anaerobic threshold (VE/VCO2 at the AT), end-tidal pressure of CO2 at the anaerobic threshold (PETCO2 at the AT), 6-min walking distance (6MWD), maximal inspiratory pressure (PImax), health-related quality of life (HRQoL), objectively-assessed spontaneous levels of physical activity, and safety (secondary end points).
Conclusions and perspectives: This trial will provide insight into biological mechanisms of the disease and indicate the potential benefits of exercise in PAH outpatients, particularly on muscle power.
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