Primary cutaneous spindle cell B-cell lymphoma of follicle origin mimicking acne rosacea. [caso clínico]
Por: Garrido Ruiz, María Concepción [Anatomía Patológica]
| Riveiro Falkenbach, Erica [Instituto de Investigación i+12] | Rodríguez Peralto, José Luis [Anatomía Patológica].
Colaborador(es): Instituto de Investigación imas12 | Servicio de Anatomía Patológica.
Tipo de material: 
ArtículoEditor: The American Journal of dermatopathology, 2015Descripción: 37(6):e64-7.Recursos en línea: Solicitar documento Resumen: Primary cutaneous spindle cell lymphoma is a unique morphologic variant of cutaneous B-cell follicle center lymphoma characterized by a prominent population of spindle-shaped, medium, and large B lymphocytes with a poorly formed storiform pattern.We report a case of a 35-year-old woman who presented with a well-defined erythematous plaque with 2 nodular, nontender nonscaling nonulcerated lesions on her right cheek mimicking acne rosacea. Microscopic examination revealed a tumor mainly centered in the reticular dermis and mostly composed of spindle-shaped large B lymphocytes exhibiting bizarre shapes with "boomerang-like" or "spermatozoa-like" appearance. The immunohistochemical staining demonstrated neoplastic lymphocytes positive for CD20, CD79α, and BCL-6, and negative for CD3, CD43, CD10, BCL-2, and MUM-1. These results supported the diagnosis of a follicle center B-cell lymphoma with spindle cells.Although this rare variant of primary cutaneous B-cell lymphoma is not included in the recent WHO-EORTC classification, the rarity of this tumor and its unique morphologic appearance frequently leads to misdiagnosis and delays its treatment.
| Tipo de ítem | Ubicación actual | Signatura | Estado | Fecha de vencimiento |
|---|---|---|---|---|
Caso clínico
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PC17272 (Navegar estantería) | Disponible |
Formato Vancouver:
Garrido MC, Rios JJ, Riveiro Falkenbach E, Escamez PJ, Ronco MA, Rodríguez Peralto JL. Primary cutaneous spindle cell B-cell lymphoma of follicle origin mimicking acne rosacea. Am J Dermatopathol. 2015 Jun;37(6):e64-7.
PMID: 25229568
Contiene 9 referencias
Primary cutaneous spindle cell lymphoma is a unique morphologic variant of cutaneous B-cell follicle center lymphoma characterized by a prominent population of spindle-shaped, medium, and large B lymphocytes with a poorly formed storiform pattern.We report a case of a 35-year-old woman who presented with a well-defined erythematous plaque with 2 nodular, nontender nonscaling nonulcerated lesions on her right cheek mimicking acne rosacea. Microscopic examination revealed a tumor mainly centered in the reticular dermis and mostly composed of spindle-shaped large B lymphocytes exhibiting bizarre shapes with "boomerang-like" or "spermatozoa-like" appearance. The immunohistochemical staining demonstrated neoplastic lymphocytes positive for CD20, CD79α, and BCL-6, and negative for CD3, CD43, CD10, BCL-2, and MUM-1. These results supported the diagnosis of a follicle center B-cell lymphoma with spindle cells.Although this rare variant of primary cutaneous B-cell lymphoma is not included in the recent WHO-EORTC classification, the rarity of this tumor and its unique morphologic appearance frequently leads to misdiagnosis and delays its treatment.
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