Formato Vancouver:
Genre F, López Mejías R, García Bermúdez M, Castañeda S, González Juanatey C, Llorca J et al. Osteoprotegerin CGA haplotype protection against cerebrovascular complications in anti-CCP negative patients with rheumatoid arthritis. PLoS One. 2014 Sep 3;9(9):e106823.

PMID: 25184828
PMC4153690

Contiene 45 referencias

Introduction: Rheumatoid arthritis is an inflammatory disease with high incidence of cardiovascular disease due to
accelerated atherosclerosis. Osteoprotegerin (OPG) has been associated with increased risk of atherosclerotic disease in the
general population. Several polymorphisms in the OPG gene with functional effects on cardiovascular disease in nonrheumatic
individuals have been described. Therefore, we aimed to analyze the effect of three of these functional OPG
polymorphisms on the risk of cardiovascular disease in a large and well-characterized cohort of Spanish patients with
rheumatoid arthritis.
Methods: Three OPG gene variants (rs3134063, rs2073618 and rs3134069) were genotyped by TaqMan assays in 2027
Spanish patients with rheumatoid arthritis. Anti-cyclic citrullinated peptide (anti-CCP) antibody testing was positive in 997 of
1714 tested. Also, 18.3% of the whole series had experienced cardiovascular events, including 5.4% with cerebrovascular
accidents. The relationship between OPG variants and cardiovascular events was assessed using Cox regression.
Results: No association between OPG gene variants and cardiovascular disease was observed in the whole group of
rheumatoid arthritis patients or in anti-CCP positive patients. Nevertheless, a protective effect of CGA haplotype on the risk
of cardiovascular disease in general, and specifically in the risk of cerebrovascular complications after adjusting for sex, age
at disease diagnosis and traditional cardiovascular risk factors was disclosed in anti-CCP negative patients (HR = 0.54; 95%CI:
0.31–0.95; p = 0.032 and HR = 0.17; 95%CI: 0.04–0.78; p = 0.022, respectively).
Conclusion: Our results indicate a protective effect of the OPG CGA haplotype on cardiovascular risk, mainly due to a
protective effect against cerebrovascular events in anti-CCP negative rheumatoid arthritis patients.