Incidence of human papillomavirus-related oropharyngeal cancer and outcomes after chemoradia82-6tion in a population of heavy smokers. [artículo]
Por: Ruiz Alonso, Ana [Oncología Radioterápica]
| Ballestín Carcavilla, Claudio [Anatomía Patológica].
Colaborador(es): Servicio de Oncología Radioterápica | Servicio de Anatomía Patológica.
Tipo de material: 
ArtículoEditor: Head & neck, 2014Descripción: 36(6):7.Recursos en línea: Solicitar documento Resumen: Background: Incidence of human papillomavirus (HPV)-related oropharyngeal carcinomas is increasing worldwide. The purpose of this study was to report the incidence in our region, and to determine the influence of HPV status on survival among a heavy smoking population.
Methods: p16 expression was analyzed in 102 patients with stage II to IV treated with chemoradiation. Overall survival (OS), locoregional control, and disease-free survival (DFS) were compared for HPV+ and HPV- status.
Results: The majority of patients were smokers (86%). p16 positivity was found in 26.7%. Patients who were HPV+ were younger (56 vs 59 years old; p = .052). No differences were observed regarding tumor stage, sex, or smoking between HPV+ and HPV-. Three-year OS was 67.4% for patients who were HPV+ versus 49.7% for HPV- (hazard ratio [HR], 0.55; p = .095).
Conclusion: Incidence of HPV-related oropharyngeal carcinoma in Spain is similar to that reported in other European countries. In this sample of heavy smokers, we observed a nonsignificant trend for better outcomes in patients who were HPV+.
| Tipo de ítem | Ubicación actual | Signatura | Estado | Fecha de vencimiento |
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Artículo
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PC16352 (Navegar estantería) | Disponible |
Formato Vancouver:
Cerezo L, López C, de la Torre A, Suárez D, Hervás A, Ruiz A et al. Incidence of human papillomavirus-related oropharyngeal cancer and outcomes after chemoradia82-6tion in a population of heavy smokers. Head Neck. 2014 Jun;36(6):7.
PMID: 23616290
Contiene 24 referencias
Background: Incidence of human papillomavirus (HPV)-related oropharyngeal carcinomas is increasing worldwide. The purpose of this study was to report the incidence in our region, and to determine the influence of HPV status on survival among a heavy smoking population.
Methods: p16 expression was analyzed in 102 patients with stage II to IV treated with chemoradiation. Overall survival (OS), locoregional control, and disease-free survival (DFS) were compared for HPV+ and HPV- status.
Results: The majority of patients were smokers (86%). p16 positivity was found in 26.7%. Patients who were HPV+ were younger (56 vs 59 years old; p = .052). No differences were observed regarding tumor stage, sex, or smoking between HPV+ and HPV-. Three-year OS was 67.4% for patients who were HPV+ versus 49.7% for HPV- (hazard ratio [HR], 0.55; p = .095).
Conclusion: Incidence of HPV-related oropharyngeal carcinoma in Spain is similar to that reported in other European countries. In this sample of heavy smokers, we observed a nonsignificant trend for better outcomes in patients who were HPV+.
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