Effect of early risedronate treatment on bone mineral density and bone turnover markers after liver transplantation: a prospective single-center study [artículo]
Por: Guadalix Iglesias, Sonsoles [Endocrinología y Nutrición]
| Martínez Díaz-Guerra, Guillermo [Endocrinología y Nutrición] | Vargas Gallego, Carmela [Bioquímica Clínica] | Moreno González, Enrique [Cirugía General y del Aparato Digestivo] | Hawkins Carranza, Federico Gustavo [Endocrinología y Nutrición] | Lora Pablos, David [Instituto Investigación I+12].
Colaborador(es): Servicio de Endocrinología y Nutrición | Unidad de Epidemiología Clínica | Servicio de Bioquímica Clínica | Servicio de Cirugía General y del Aparato Digestivo.
Editor: Transplant International, 2011Descripción: 24(7):657-665.Recursos en línea: Solicitar documento Resumen: The aim of this study was to investigate the effect of risedronate (RIS) on bone loss and bone turnover markers after liver transplantation (LT). Patients with osteopenia or osteoporosis within the first month after LT were randomized to receive RIS 35 mg/week plus calcium 1000 mg/day and vitamin D(3) 800 IU/day (n = 45) or calcium and vitamin D(3) at same dosages (n = 44). Primary endpoint was change in bone mineral density (BMD) 6 and 12 months after LT. Secondary endpoints included changes in serum β-CrossLaps (β-CTX) and procollagen type 1 amino-terminal peptide (P1NP) and fracture rate. Spine X-rays were obtained at baseline and after 12 months. There was no significant difference in BMD changes between both treatment groups at any sites; either at 6 or 12 months. Spine BMD increased in both groups at 12 months vs. baseline (P = 0.001). RIS patients had a significant increase in intertrochanteric BMD at 12 months (P < 0.05 vs. baseline). Serum β-CTX decreased in both groups (P < 0.01), with significant differences between groups at 3 months. No significant difference in vertebral fracture incidence was found. After 12 months, BMD improved at lumbar spine and did not change at hip in both groups. Significant differences between both groups were not found. Other factors (calcium and vitamin D replacement, early prednisone withdrawal) seem to have also positive effects in BMD.
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Formato Vancouver:
Guadalix S, Martínez Díaz-Guerra G, Lora D, Vargas C, Gómez-Juaristi M, Cobaleda B, et al. Effect of early risedronate treatment on bone mineral density and bone turnover markers after liver transplantation: a prospective single-center study. Transpl Int. 2011;24(7):657-65.10.1111/j.1432-2277.2011.01253.x.
PMID:21466595
Contiene 27 referencias.
The aim of this study was to investigate the effect of risedronate (RIS) on bone loss and bone turnover markers after liver transplantation (LT). Patients with osteopenia or osteoporosis within the first month after LT were randomized to receive RIS 35 mg/week plus calcium 1000 mg/day and vitamin D(3) 800 IU/day (n = 45) or calcium and vitamin D(3) at same dosages (n = 44). Primary endpoint was change in bone mineral density (BMD) 6 and 12 months after LT. Secondary endpoints included changes in serum β-CrossLaps (β-CTX) and procollagen type 1 amino-terminal peptide (P1NP) and fracture rate. Spine X-rays were obtained at baseline and after 12 months. There was no significant difference in BMD changes between both treatment groups at any sites; either at 6 or 12 months. Spine BMD increased in both groups at 12 months vs. baseline (P = 0.001). RIS patients had a significant increase in intertrochanteric BMD at 12 months (P < 0.05 vs. baseline). Serum β-CTX decreased in both groups (P < 0.01), with significant differences between groups at 3 months. No significant difference in vertebral fracture incidence was found. After 12 months, BMD improved at lumbar spine and did not change at hip in both groups. Significant differences between both groups were not found. Other factors (calcium and vitamin D replacement, early prednisone withdrawal) seem to have also positive effects in BMD.
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