A profibrotic role for thymic stromal lymphopoietin in systemic sclerosis. [artículo]
Por: Carreira Delgado, Patricia Esmeralda [Reumatología]
| Criado Carrasco, Gabriel [Instituto de Investigación i+12] | Rey Cerros, Manuel José del [Instituto de Investigación i+12] | Izquierdo Alvárez, Elena [Instituto de Investigación i+12] | Ortiz Romero, Pablo Luis [Dermatología Médico-Quirúrgica y Venereología] | Pablos Álvarez, José Luis [Reumatología] | Usátegui Corral, Alicia [Instituto de Investigación i+12].
Colaborador(es): Servicio de Reumatología | Servicio de Dermatología Médico-Quirúrgica y Venereología | Instituto de Investigación imas12.
Editor: Annals of the rheumatic diseases, 2013Descripción: 72(12):2018-23.Recursos en línea: Solicitar documento Resumen: Systemic sclerosis (SSc) is an autoimmune disease characterised by progressive fibrosis. Although SSc shares pathogenetic features with other autoimmune diseases, the participation of profibrotic Th2 cytokines is unique to SSc, but the mechanisms of Th2 skewing are unknown. We have analysed the expression and function of thymic stromal lymphopoietin (TSLP), a central regulator of Th2-mediated allergic inflammation, in human SSc, primary lung fibrosis and in a mouse model of scleroderma.
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Artículo
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Formato Vancouver:
Usategui A, Criado G, Izquierdo E, Del Rey MJ, Carreira PE, Ortiz P et al. A profibrotic role for thymic stromal lymphopoietin in systemic sclerosis. Ann Rheum Dis. 2013 Dec;72(12):2018-23.
PMID: 23413283
Contiene 44 referencias
Systemic sclerosis (SSc) is an autoimmune disease characterised by progressive fibrosis. Although SSc shares pathogenetic features with other autoimmune diseases, the participation of profibrotic Th2 cytokines is unique to SSc, but the mechanisms of Th2 skewing are unknown. We have analysed the expression and function of thymic stromal lymphopoietin (TSLP), a central regulator of Th2-mediated allergic inflammation, in human SSc, primary lung fibrosis and in a mouse model of scleroderma.
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