Calmodulin levels in blood cells as a potential biomarker of Alzheimer's disease. [artículo]
Por: Bermejo Pareja, Félix [Neurología]
| Villarejo Galende, Alberto [Neurología].
Colaborador(es): Servicio de Neurología-Neurofisiología.
Editor: Alzheimers Research & Therapy, 2013Descripción: 5(6):55.Recursos en línea: Acceso libre Resumen: The clinical features of Alzheimer's disease (AD) overlap with a number of other dementias and conclusive diagnosis is only achieved at autopsy. Accurate in-life diagnosis requires finding biomarkers suitable for early diagnosis, as well as for discrimination from other types of dementia. Mounting evidence suggests that AD-dependent processes may also affect peripheral cells. We previously reported that calmodulin (CaM) signaling is impaired in AD lymphoblasts. Here, we address the issue as to whether the assessment of CaM levels in peripheral cells could serve as a diagnostic biomarker. Methods: A total of 165 subjects were enrolled in the study, including
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Artículo
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Formato Vancouver:
Esteras N, Alquézar C, de la Encarnación A, Villarejo A, Bermejo-Pareja F, Martín-Requero A. Calmodulin levels in blood cells as a potential biomarker of Alzheimer's disease. Alzheimers Res Ther. 2013 Nov 7;5(6):55.
PMID: 24499616
Contiene 48 referencias
The clinical features of Alzheimer's disease (AD) overlap with a number of other dementias and conclusive diagnosis is only achieved at autopsy. Accurate in-life diagnosis requires finding biomarkers suitable for early diagnosis, as well as for discrimination from other types of dementia. Mounting evidence suggests that AD-dependent processes may also affect peripheral cells. We previously reported that calmodulin (CaM) signaling is impaired in AD lymphoblasts. Here, we address the issue as to whether the assessment of CaM levels in peripheral cells could serve as a diagnostic biomarker. Methods: A total of 165 subjects were enrolled in the study, including
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