Azcárate, Isabel G. Bautista, José M. Díez, Amalia Puyet, Antonio
Malaria proteomics: Insights into the parasite-host interactions in the pathogenic space. [artículo] - Journal of proteomics, 2014 - 97:107-25.
Formato Vancouver:
Bautista JM, Marín-García P, Diez A, Azcárate IG, Puyet A. Malaria proteomics: insights into the parasite-host interactions in the pathogenic space. J Proteomics. 2014 Jan 31;97:107-25.
PMID: 24140976
Contiene 145 referencias
Proteomics is improving malaria research by providing global information on relevant protein sets from the parasite and the host in connection with its cellular structures and specific functions. In the last decade, reports have described biologically significant elements in the proteome of Plasmodium, which are selectively targeted and quantified, allowing for sensitive and high-throughput comparisons. The identification of molecules by which the parasite and the host react during the malaria infection is crucial to the understanding of the underlying pathogenic mechanisms. Hence, proteomics is playing a major role by defining the elements within the pathogenic space between both organisms that change across the parasite life cycle in association with the host transformation and response. Proteomics has identified post-translational modifications in the parasite and the host that are discussed in terms of functional interactions in malaria parasitism. Furthermore, the contribution of proteomics to the investigation of immunogens for potential vaccine candidates is summarized. The malaria-specific technological advances in proteomics are particularly suited now for identifying host-parasite interactions that could lead to promising targets for therapy, diagnosis or prevention. In this review, we examine the knowledge gained on the biology, pathogenesis, immunity and diagnosis of Plasmodium infection from recent proteomic studies. This article is part of a Special Issue entitled: Trends in Microbial Proteomics.
Malaria proteomics: Insights into the parasite-host interactions in the pathogenic space. [artículo] - Journal of proteomics, 2014 - 97:107-25.
Formato Vancouver:
Bautista JM, Marín-García P, Diez A, Azcárate IG, Puyet A. Malaria proteomics: insights into the parasite-host interactions in the pathogenic space. J Proteomics. 2014 Jan 31;97:107-25.
PMID: 24140976
Contiene 145 referencias
Proteomics is improving malaria research by providing global information on relevant protein sets from the parasite and the host in connection with its cellular structures and specific functions. In the last decade, reports have described biologically significant elements in the proteome of Plasmodium, which are selectively targeted and quantified, allowing for sensitive and high-throughput comparisons. The identification of molecules by which the parasite and the host react during the malaria infection is crucial to the understanding of the underlying pathogenic mechanisms. Hence, proteomics is playing a major role by defining the elements within the pathogenic space between both organisms that change across the parasite life cycle in association with the host transformation and response. Proteomics has identified post-translational modifications in the parasite and the host that are discussed in terms of functional interactions in malaria parasitism. Furthermore, the contribution of proteomics to the investigation of immunogens for potential vaccine candidates is summarized. The malaria-specific technological advances in proteomics are particularly suited now for identifying host-parasite interactions that could lead to promising targets for therapy, diagnosis or prevention. In this review, we examine the knowledge gained on the biology, pathogenesis, immunity and diagnosis of Plasmodium infection from recent proteomic studies. This article is part of a Special Issue entitled: Trends in Microbial Proteomics.
