Franco Ugidos, Alejandro
Second-line Therapy With Levofloxacin After Failure of Treatment to Eradicate Helicobacter pylori Infection Time Trends in a Spanish Multicenter Study of 1000 Patients. [artículo] - Journal of clinical gastroenterology, 2013 - 47(2):130-5.
Formato Vancouver:
Gisbert JP, Pérez-Aisa A, Bermejo F, Castro-Fernández M, Almela P, Barrio J et al. H. pylori Study Group of the Asociación Española de Gastroenterología (Spanish Gastroenterology Association). Second-line therapy with levofloxacin after failure of treatment to eradicate helicobacter pylori infection: time trends in a Spanish Multicenter Study of 1000 patients. J Clin Gastroenterol. 2013 Feb;47(2):130-5.
PMID: 22647827
Contiene 47 referencias
Background: Second-line bismuth-containing quadruple therapy is complex and frequently induces adverse effects. A triple rescue regimen containing levofloxacin is a potential alternative; however, resistance to quinolones is rapidly increasing. Aim: To evaluate the efficacy and tolerability of a second-line triple-regimen-containing levofloxacin in patients whose Helicobacter pylori eradication treatment failed and to assess whether the efficacy of the regimen decreases with time. Methods: Design: Prospective multicenter study. Patients: In whom treatment with a regimen comprising a proton-pump inhibitor, clarithromycin, and amoxicillin had failed. Intervention: Levofloxacin (500mg bid), amoxicillin (1 g bid), and omeprazole (20mg bid) for 10 days. Outcome: Eradication was confirmed using the C-13-urea breath test 4 to 8 weeks after therapy. Compliance/tolerance: Compliance was determined through questioning and recovery of empty medication envelopes. Incidence of adverse effects was evaluated by means of a questionnaire.
Second-line Therapy With Levofloxacin After Failure of Treatment to Eradicate Helicobacter pylori Infection Time Trends in a Spanish Multicenter Study of 1000 Patients. [artículo] - Journal of clinical gastroenterology, 2013 - 47(2):130-5.
Formato Vancouver:
Gisbert JP, Pérez-Aisa A, Bermejo F, Castro-Fernández M, Almela P, Barrio J et al. H. pylori Study Group of the Asociación Española de Gastroenterología (Spanish Gastroenterology Association). Second-line therapy with levofloxacin after failure of treatment to eradicate helicobacter pylori infection: time trends in a Spanish Multicenter Study of 1000 patients. J Clin Gastroenterol. 2013 Feb;47(2):130-5.
PMID: 22647827
Contiene 47 referencias
Background: Second-line bismuth-containing quadruple therapy is complex and frequently induces adverse effects. A triple rescue regimen containing levofloxacin is a potential alternative; however, resistance to quinolones is rapidly increasing. Aim: To evaluate the efficacy and tolerability of a second-line triple-regimen-containing levofloxacin in patients whose Helicobacter pylori eradication treatment failed and to assess whether the efficacy of the regimen decreases with time. Methods: Design: Prospective multicenter study. Patients: In whom treatment with a regimen comprising a proton-pump inhibitor, clarithromycin, and amoxicillin had failed. Intervention: Levofloxacin (500mg bid), amoxicillin (1 g bid), and omeprazole (20mg bid) for 10 days. Outcome: Eradication was confirmed using the C-13-urea breath test 4 to 8 weeks after therapy. Compliance/tolerance: Compliance was determined through questioning and recovery of empty medication envelopes. Incidence of adverse effects was evaluated by means of a questionnaire.
