Hernández Laín, Aurelio
Functional evaluation of paraplegic monkeys (Macaca mulatta) over fourteen months post-lesion [artículo] - Neuroscience Research, 2011. - 69(2):144-153.
Formato Vancouver:
Hernández-Laín A, Piedras MJ, Cavada C. Functional evaluation of paraplegic monkeys (Macaca mulatta) over fourteen months post-lesion. Neurosci Res. 2011Feb;69(2):144-53.
PMID: 21093503
Contiene 29 referencias.
We report on the neurological and neurophysiological findings obtained from two adult Macaca mulatta sustaining complete spinal cord transections at T8-T9. We performed periodic neurological exams, recorded motor evoked potentials (MEPs) following transcranial magnetic stimulation (TMS), and recorded electromyograms (EMGs) during the execution of a lower limb motor test. The main observations were: (1) the spinal shock period lasted less than a week; tendon, cutaneous and withdrawal reflexes were uneven in range and occurrence, and Babinski's sign was not observed; (2) a protracted functional lesion in the tibial and common peroneal nerves appeared bilaterally early in the post-lesional period; (3) MEPs were elicited by TMS in the quadriceps muscle of both monkeys; they were recorded as early as the 5th week after lesion in one of the monkeys, and they persisted throughout the post-lesional period in both monkeys; and (4) motor unit action potentials in the quadriceps muscle recorded by EMG were simultaneous with attempts to perform intentional lower limb movements from post-lesion month 11 to 13.5 in both monkeys. The last two sets of observations argue in favor of a partial cortico-spinal functional gain and suggest that spinal cord regeneration can occur after complete spinal cord injury in primates.
Functional evaluation of paraplegic monkeys (Macaca mulatta) over fourteen months post-lesion [artículo] - Neuroscience Research, 2011. - 69(2):144-153.
Formato Vancouver:
Hernández-Laín A, Piedras MJ, Cavada C. Functional evaluation of paraplegic monkeys (Macaca mulatta) over fourteen months post-lesion. Neurosci Res. 2011Feb;69(2):144-53.
PMID: 21093503
Contiene 29 referencias.
We report on the neurological and neurophysiological findings obtained from two adult Macaca mulatta sustaining complete spinal cord transections at T8-T9. We performed periodic neurological exams, recorded motor evoked potentials (MEPs) following transcranial magnetic stimulation (TMS), and recorded electromyograms (EMGs) during the execution of a lower limb motor test. The main observations were: (1) the spinal shock period lasted less than a week; tendon, cutaneous and withdrawal reflexes were uneven in range and occurrence, and Babinski's sign was not observed; (2) a protracted functional lesion in the tibial and common peroneal nerves appeared bilaterally early in the post-lesional period; (3) MEPs were elicited by TMS in the quadriceps muscle of both monkeys; they were recorded as early as the 5th week after lesion in one of the monkeys, and they persisted throughout the post-lesional period in both monkeys; and (4) motor unit action potentials in the quadriceps muscle recorded by EMG were simultaneous with attempts to perform intentional lower limb movements from post-lesion month 11 to 13.5 in both monkeys. The last two sets of observations argue in favor of a partial cortico-spinal functional gain and suggest that spinal cord regeneration can occur after complete spinal cord injury in primates.
