Morán Jiménez, María Josefa
Mitochondrial biogenesis related endurance genotype score and sports performance in athletes [artículo] - Mitochondrion, 2011 - 11(1):64-69.
Formato Vancouver:
Eynon N, Ruiz JR, Meckel Y, Morán M, Lucia A. Mitochondrial biogenesis related endurance genotype score and sports performance in athletes. Mitochondrion. 2011 ;11(1):64-9.
PMID:20647061
Contiene 32 referencias
We determined the probability of individuals having the 'optimal' mitochondrial biogenesis related endurance polygenic profile, and compared the endurance polygenic profile of Israeli (Caucasian) endurance athletes (n = 74), power athletes (n = 81), and non-athletes (n = 240). We computed a mitochondrial biogenesis related 'endurance genotype score' (EGS, scoring from 0 to 100) from the accumulated combination of six polymorphisms in the PPARGC1A-NRF-TFAM pathway. Some of the variant alleles of the polymorphisms studied were so infrequent, that the probability of possessing an 'optimal' EGS (= 100) was 0% in the entire study population. However, the EGS was significantly higher (P<0.001) in endurance athletes (38.9 +/- 17.1) compared with controls (30.6 +/- 12.4) or power athletes (29.0 +/- 11.2). In summary, although the probability of an individual possessing a theoretically 'optimal' genetic background for endurance sports is very low, in general endurance athletes have a polygenic profile that is more suitable for mitochondrial biogenesis.
Mitochondrial biogenesis related endurance genotype score and sports performance in athletes [artículo] - Mitochondrion, 2011 - 11(1):64-69.
Formato Vancouver:
Eynon N, Ruiz JR, Meckel Y, Morán M, Lucia A. Mitochondrial biogenesis related endurance genotype score and sports performance in athletes. Mitochondrion. 2011 ;11(1):64-9.
PMID:20647061
Contiene 32 referencias
We determined the probability of individuals having the 'optimal' mitochondrial biogenesis related endurance polygenic profile, and compared the endurance polygenic profile of Israeli (Caucasian) endurance athletes (n = 74), power athletes (n = 81), and non-athletes (n = 240). We computed a mitochondrial biogenesis related 'endurance genotype score' (EGS, scoring from 0 to 100) from the accumulated combination of six polymorphisms in the PPARGC1A-NRF-TFAM pathway. Some of the variant alleles of the polymorphisms studied were so infrequent, that the probability of possessing an 'optimal' EGS (= 100) was 0% in the entire study population. However, the EGS was significantly higher (P<0.001) in endurance athletes (38.9 +/- 17.1) compared with controls (30.6 +/- 12.4) or power athletes (29.0 +/- 11.2). In summary, although the probability of an individual possessing a theoretically 'optimal' genetic background for endurance sports is very low, in general endurance athletes have a polygenic profile that is more suitable for mitochondrial biogenesis.
