García Hernández, Gloria Martínez Martínez, María Teresa
Bronchopulmonary infection-colonization patterns in Spanish cystic fibrosis patients: Results from a national multicenter study. [artículo] - Journal of cystic fibrosis : official journal of the European Cystic Fibrosis Society, 2016 - 15(3):357-65.
Formato Vancouver:
De Dios Caballero J, Del Campo R, Royuela A, Solé A, Máiz L, Olveira C et al; GEIFQ (Grupo Español para el Estudio de la Colonización/Infección Broncopulmonar en Fibrosis Quística). Bronchopulmonary infection-colonization patterns in Spanish cystic fibrosis patients: Results from a national multicenter study. J Cyst Fibros. 2016 May;15(3):357-65.
PMID: 26429520
Contiene 30 referencias
Background: Clinical and demographical knowledge on Spanish cystic fibrosis (CF) patients is incomplete as no national registry exists. CF-microbiology has not been studied at national level. The results of the first Spanish multicenter study on CF microbiology are presented.
Methods: 24 CF-Units for adult (n=12) and pediatric (n=12) patients from 17 hospitals provided sputa and clinical data from 15 consecutive patients. Cultures and susceptibility testing were performed. Colonization impact on pulmonary function was assessed.
Results: 341 patients [mean (SD) age 21 (11) years, 180≥18years, mean (SD) FEV1=68 (25)%] were included. Pseudomonas aeruginosa was reported as chronic, intermittent or absent in 46%, 22% and 32% of patients, respectively. The annual prevalence was 62%. Positive P. aeruginosa and methicillin-resistant Staphylococcus aureus cultures were significantly associated with lower FEV1 (p<0.001 and p=0.003, respectively).
Conclusions: The representative subset of the Spanish CF-population which has been clinically, demographically and microbiologically characterized will serve as a reference for future CF studies in Spain.
Bronchopulmonary infection-colonization patterns in Spanish cystic fibrosis patients: Results from a national multicenter study. [artículo] - Journal of cystic fibrosis : official journal of the European Cystic Fibrosis Society, 2016 - 15(3):357-65.
Formato Vancouver:
De Dios Caballero J, Del Campo R, Royuela A, Solé A, Máiz L, Olveira C et al; GEIFQ (Grupo Español para el Estudio de la Colonización/Infección Broncopulmonar en Fibrosis Quística). Bronchopulmonary infection-colonization patterns in Spanish cystic fibrosis patients: Results from a national multicenter study. J Cyst Fibros. 2016 May;15(3):357-65.
PMID: 26429520
Contiene 30 referencias
Background: Clinical and demographical knowledge on Spanish cystic fibrosis (CF) patients is incomplete as no national registry exists. CF-microbiology has not been studied at national level. The results of the first Spanish multicenter study on CF microbiology are presented.
Methods: 24 CF-Units for adult (n=12) and pediatric (n=12) patients from 17 hospitals provided sputa and clinical data from 15 consecutive patients. Cultures and susceptibility testing were performed. Colonization impact on pulmonary function was assessed.
Results: 341 patients [mean (SD) age 21 (11) years, 180≥18years, mean (SD) FEV1=68 (25)%] were included. Pseudomonas aeruginosa was reported as chronic, intermittent or absent in 46%, 22% and 32% of patients, respectively. The annual prevalence was 62%. Positive P. aeruginosa and methicillin-resistant Staphylococcus aureus cultures were significantly associated with lower FEV1 (p<0.001 and p=0.003, respectively).
Conclusions: The representative subset of the Spanish CF-population which has been clinically, demographically and microbiologically characterized will serve as a reference for future CF studies in Spain.
