Caro Teller, José Manuel Cortijo Cascajares, Susana Escribano Valenciano, Irene Serrano Garrote, Olga Ferrari Piquero, José Miguel
Uso, efectividad y seguridad de abiraterona en cáncer de próstata. [artículo] - Farmacia hospitalaria: órgano oficial de expresión científica de la Sociedad Española de Farmacia Hospitalaria, 2014 - 38(2):118-22.
Formato Vancouver:
Caro Teller JM, Cortijo Cascajares S, Escribano Valenciano I, Serrano Garrote O, Ferrari Piquero JM. Uso, efectividad y seguridad de abiraterona en cáncer de próstata. Farm Hosp. 2014 Apr 1;38(2):118-22.
PMID: 24669896
Contiene 15 referencias
Background and objective: After the marketing of Abiraterone, an androgen synthesis inhibitor, the aim of the study was to analyze its use, response, and safety in the population of a tertiary care level hospital.
Materials and methods: A retrospective observational study was carried out including all patients that were started on Abiraterone within a 21-month period. Demographical, diagnostic, therapeutic, and clinical variables were gathered. The response was assessed through the decreased of PSA as compared to baseline values. To assess the safety, all treatment-related adverse events were recorded.
Results: A total of 45 patients were included of which 88.89% could be assessed for the drug effectiveness. The median baseline PSA value was 457.31 (range 9032-2.81). PSA decrease was ≥ 50%, ≥ 90% and < 30% in 16 (40%), 3 (7.5%) y 20 (50%), respectively. The most common grade 1-2 adverse events were fatigue (35.6%), increased liver enzymes (28.9%), hipokalemia (13.3%) and fluid retention (11.1%).
Conclusions: Abiraterone was a well tolerated drug that has shown to be active in prostate cancer patients previously treated with taxans, so it has been postulated as an alternative in this pathology.
Uso, efectividad y seguridad de abiraterona en cáncer de próstata. [artículo] - Farmacia hospitalaria: órgano oficial de expresión científica de la Sociedad Española de Farmacia Hospitalaria, 2014 - 38(2):118-22.
Formato Vancouver:
Caro Teller JM, Cortijo Cascajares S, Escribano Valenciano I, Serrano Garrote O, Ferrari Piquero JM. Uso, efectividad y seguridad de abiraterona en cáncer de próstata. Farm Hosp. 2014 Apr 1;38(2):118-22.
PMID: 24669896
Contiene 15 referencias
Background and objective: After the marketing of Abiraterone, an androgen synthesis inhibitor, the aim of the study was to analyze its use, response, and safety in the population of a tertiary care level hospital.
Materials and methods: A retrospective observational study was carried out including all patients that were started on Abiraterone within a 21-month period. Demographical, diagnostic, therapeutic, and clinical variables were gathered. The response was assessed through the decreased of PSA as compared to baseline values. To assess the safety, all treatment-related adverse events were recorded.
Results: A total of 45 patients were included of which 88.89% could be assessed for the drug effectiveness. The median baseline PSA value was 457.31 (range 9032-2.81). PSA decrease was ≥ 50%, ≥ 90% and < 30% in 16 (40%), 3 (7.5%) y 20 (50%), respectively. The most common grade 1-2 adverse events were fatigue (35.6%), increased liver enzymes (28.9%), hipokalemia (13.3%) and fluid retention (11.1%).
Conclusions: Abiraterone was a well tolerated drug that has shown to be active in prostate cancer patients previously treated with taxans, so it has been postulated as an alternative in this pathology.
